Evidence is accumulating that fructose (‘vruchtensuiker’) contributes to the development of non-alcoholic fatty liver disease, hypertension, type 2 diabetes and coronary artery disease.
We are looking for someone highly motivated and with a degree in Medicine or Biomedical Sciences (or a comparable degree) who is interested in an ambitious PhD project. The PhD student will perform an intervention with a completely new drug that affects fructose metabolism. State-of-the-art techniques will be used to evaluate the treatment effect, including hyperinsulinemic-euglycemic clamps to assess insulin sensitivity, magnetic resonance spectroscopy to quantify liver fat fractions, and tissue biopsies to study detailed mechanisms. The PhD student will be trained in performing these measurements, as well as the principles of clinical research and statistical analyses.
This practical study offers an excellent introduction into clinical research and may serve as a mutual acquaintance for those MD’s who are interested in specialty training at the Department of Internal Medicine.
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