PhD candidate' Energy for Life: Coupling Magnesium and ATP’

Updated: 3 months ago
Job Type: Temporary
Deadline: 29 Sep 2022

We are looking for an enthousiastic PhD candidate to join our project 'Energy for Life: Coupling Magnesium and ATP'In this project. We aim to elucidate the exact composition and function of the CNNM-TRPM7 magnesium channel complex. Moreover, the regulation of CNNM-TRPM7 by ATP and nutrient sensors AMPK and mTOR will be investigated. In the final part of the project, the metabolic consequences of CNNM-TRPM7 activity will be mapped. Will you join our team?

Cells require energy for their activity and growth. In order to respond to changes in nutrient availability, eukaryotic cells have strategies to rapidly change their metabolic activity and switch between energy sources. The control of these metabolic pathways is essential for cell survival. Deranged energy metabolism inevitably results in disease. For instance, altered cellular energy metabolism is a hallmark of cancer, facilitating maximal cell growth and proliferation.

Adenosine triphosphate (ATP) is the main energy source for cellular processes. For its stability and function, ATP requires binding to magnesium ions. Therefore, magnesium uptake of cells should be carefully balanced with ATP production. Upon activation of ATP production, magnesium influx is increased.
Magnesium uptake in cells is regulated by the concerted action of magnesium channels and transporters in the plasma membrane.

Tasks and responsibilities

  • Apply state-of-the art microscopy to monitor the composition and the function of magnesium transport complexes.
  • Map the metabolic adaptations of cells in response to magnesium and nutrient deficiencies using metabolomics and biochemical measurements.
  • Work in a multidisciplinary team of scientists, clinicians and patients to improve the diagnostics and therapy of patients with Mg2+ wasting tubulopathies. It is an international research group with fellows from many countries.
  • Design and perform scientific research in the area of cell biology, biochemistry and physiology.
  • Generate and analyse the data in order to contribute to scientific publications and presents findings at scientific meetings.
  • Perform research in a stimulating environment with your team.
  • Complete the project with a scientific dissertation.

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