PhD candidate 'Dosimetry of radionuclide therapy in cancer'

16 Mar 2024
Job Information

Organisation/Company

Radboud University Medical Center (Radboudumc)

Research Field

Medical sciences

Researcher Profile

First Stage Researcher (R1)

Country

Netherlands

Application Deadline

11 Apr 2024 - 22:00 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

36.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Are you the ambitious PhD candidate we are looking for to further develop radionuclide therapy into an effective and widely available treatment for cancer patients? We would like to get to know you!

In radionuclide therapy, a tumor-targeting vector is coupled to a therapeutic radionuclide to specifically irradiate tumor lesions from inside the body. This approach allows for the delivery of a high radiation absorbed dose to (metastasized) tumor lesions, while sparing healthy tissues. Despite the high potential of treatment, we currently do not know which type of radionuclide is most effective to kill cancer cells and what is its underlying mechanism of action. Within this NWO funded consortium project “UNRANU ” we aim to unravel the radiobiological effects of radionuclide therapy and contribute to novel production methods for therapeutic radionuclides and patient-specific treatment. More specifically, your task will be to develop dosimetry models to calculate the tumor-absorbed dose in cell experiments, 3D organoid models, and mouse tumor models and to correlate the absorbed dose to the biological effects.

Work in a large consortium and closely connect with different stake holders from academia, industry and society (e.g. TU Delft, ErasmucMC, NRG|PALLAS, AlfaRIM, HUB Organoids, MILabs, Quirem Medical, RTM, Siemens Healthineers, TerThera, URENCO, Von Gahlen, VSL RIVM, Wetenschapsknooppunt, patient organisations) to plan, discuss, and perform research in a stimulating environment.

Tasks and responsibilities

• Develop dosimetric models to calculate (heterogeneous) tumor-absorbed doses for in vitro cell culture, 3D organoids, and mouse experiments.
• Correlate the absorbed dose-calculations with the biological outcome after radionuclide therapy.
• Analyze scientific data.
• Write scientific publications and present findings at (inter)national scientific meetings.

Requirements
Specific Requirements

You have well-developed communicational and social skills directed towards working in a team. You have strong analytical and problem-solving skills. You are enthusiastic and have a strong motivation to successfully complete a PhD. You have interest for and are trained in radiation physics, radiation biology, radiation safety, or dosimetry.

Further you recognize yourself in the profile below:

• Masters degree in (bio)physics, health physics, technical medicine, clinical technology, or equivalent.
• Experience with Geant4 or other relevant software tools used for dose calculations and treatment planning (e.g. Monte Carlo codes, image segmentation, Python).
• Permit to work with radioactivity (or willing to obtain this permit).

Additional Information
Benefits

At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:

• Upon commencement of employment, you will start at scale 10A, step 0 (€2,901 based on a full-time appointment). Over a maximum period of 4 years, you will progress to scale 10A, step 3 (€3,677 based on a full-time appointment). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and a 47% to 72% bonus for working unsocial hours.
• Plenty of opportunities for personal development. You can take a variety of courses in our online learning environment. You can also share knowledge with colleagues through digital learning spaces – perfect for getting inspired and inspiring others.
• Your well-being and vitality are our priorities. For instance, you can enjoy a 40% discount on a sports subscription at the Radboud Sports Center along with access to the Healthy Professionals program designed to assist you in managing your energy. If you are going through a life-changing event, our Company Support Team and a personal coach are there to help you.
• Support in achieving a good work-life balance at every stage of your life. This includes advice and training courses (from ‘Millennial Dilemmas’ to ‘Your Career After 57’), activities at our own mindfulness center , and informal caregiving consultations if you have questions about juggling work and caregiving responsibilities at home.
• 168 holiday hours per year (23 days) based on a 36-hour working week.
• 26 weeks of parental leave, nine of which are paid.
• Pension accrual with the ABP Pension Fund. Radboudumc pays 70% of the pension premium.
• Discounts on health insurance and ten other types of insurance, from home insurance to legal assistance.
• An allowance for your travel expenses or a working-from-home allowance of €2 per day.

Selection process

Any questions? Or wondering what it is like to work at Radboudumc? Then call or email to Professor Sandra Heskamp , Dr. Frank Nijsen or Dr. Mark Konijnenberg , trough +31 024 361 45 11. Use the Apply button to submit your application.

Additional comments

Any questions? Or wondering what it is like to work at Radboudumc? Then call or email to Professor Sandra Heskamp , Dr. Frank Nijsen or Dr. Mark Konijnenberg , trough +31 024 361 45 11. Use the Apply button to submit your application.

Website for additional job details

https://www.academictransfer.com/339112/

Work Location(s)

Number of offers available

1

Company/Institute

Radboudumc

Country

Netherlands

City

Nijmegen

Postal Code

6525 GA

Street

Geert Grooteplein-Zuid 10

Geofield

Where to apply

Website

https://www.academictransfer.com/en/339112/phd-candidate-dosimetry-of-radionucl…

Contact

City

Nijmegen

Website

http://www.radboudumc.nl/

Street

Geert Grooteplein-Zuid 10

Postal Code

6525 GA

STATUS: EXPIRED