PhD candidate 'Cancer metastasis and immunotherapy: Monitoring drug effects in vivo'

10 Feb 2024
Job Information

Organisation/Company

Radboud University Medical Center (Radboudumc)

Research Field

Medical sciences
Physics

Researcher Profile

First Stage Researcher (R1)

Country

Netherlands

Application Deadline

10 Mar 2024 - 23:00 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

36.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

As a PhD candidate you will become part of the NIH/NCI sponsored Cancer MetNet Center on 'Mechanical determinants of organ-selective metastatic colonization, dormancy, and outgrowth ' focussed on the mechanobiology and targeting of early steps of cancer metastasis.

Our programme aims to transform cell biology by developing and applying advanced microscopy and real-time molecular manipulation techniques to study the first hours and days during organ colonization and identify molecular interference points to overcome metastatic ability. The consortium forms a unique and highly interdisciplinary team that combines intravital microscopy with organ on a chip technology, in vivo cell biology, mathematical modelling as well as chemical and genetic cell manipulation to study cancer metastasis. Read more about the overall MetNet Center description.

As a PhD candidate in Friedl lab at Radboud University Medical Centre, Nijmegen, you will study the effect of drugs and molecular interventions in epithelial and mesenchymal tumor models in vivo. You will apply in vivo microscopy, multi-spectral 3D tissue mapping, single-cell molecular profiling and inducible tools to record and manipulate cytoskeletal pathways and newly identified pathways in order to interfere with tumor cell survival and metastatic progression. The use of these tools will also be expanded to study the effects on tumor cell resistance, their response to immune cell attack, in collaboration with other team members working on the MetNet project. Click here for the overall framework for this PhD position.

This position is part of the NIH-funded U54 MetNet consortium . MetNet is an interdisciplinary programme combining cell and molecular biology, as well as mouse models to study the process cell behaviour in development and cancer, and targeted drug delivery. Participating institutes are based throughout the USA, with only one site on intravital microscopy located in the Netherlands.

Tasks and responsibilities

• Design and perform scientific research in the area of cell biology, microscopy in mouse models of cancer metastasis and molecular pharmacology.
• Generate and analyse the data in order to contribute to scientific publications and present findings at scientific meetings.
• Work in a team with other students of the MetNet consortium and scientists to discuss, plan and perform research in a stimulating environment.
• Work in an international research group with fellows several countries, including the USA.
• Complete the project with a scientific dissertation.

Requirements
Specific Requirements

We are looking for a highly motivated and creative candidate to join us in this unique project. We would like you to bring:

• A PhD degree in cancer research, immunology or a related field.
• A background in preclinical cancer models (in mice), cell biology, molecular biology and great interest in advanced microscopy.
• Analytical and problem solving skills.
• Proficiency in written and spoken English.
• Article 9 Certificate for animal experiments, or equivalent.

If you feel that this role is the perfect match, but you do not yet meet all the qualifications, we also welcome you to apply.

Additional Information
Benefits

At Radboud university medical center, you build on your future. We are committed to providing the best care, education, and research. And we are true to our word, because we help you develop and seize opportunities and give you the room to grow. As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:

• Upon commencement of employment, you will start at scale 10A, step 0 (€2,901 based on a full-time appointment). Over a maximum period of 4 years, you will progress to scale 10A, step 3 (€3,677 based on a full-time appointment). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and a 47% to 72% bonus for working unsocial hours.
• Plenty of opportunities for personal development. You can take a variety of courses in our online learning environment. You can also share knowledge with colleagues through digital learning spaces – perfect for getting inspired and inspiring others.
• Your well-being and vitality are our priorities. For instance, you can enjoy a 40% discount on a sports subscription at the Radboud Sports Center along with access to the Healthy Professionals program designed to assist you in managing your energy. If you are going through a life-changing event, our Company Support Team and a personal coach are there to help you.
• Support in achieving a good work-life balance at every stage of your life. This includes advice and training courses (from ‘Millennial Dilemmas’ to ‘Your Career After 57’), activities at our own mindfulness center , and informal caregiving consultations if you have questions about juggling work and caregiving responsibilities at home.
• 168 holiday hours per year (23 days) based on a 36-hour working week.
• 26 weeks of parental leave, nine of which are paid.
• You build up a pension by ABP Pension Fund, and Radboudumc pays 70% of the pension premium.
• Discounts on health insurance and ten other types of insurance, from home insurance to legal assistance.
• An allowance for your travel expenses or a working-from-home allowance of €2 per day.

Selection process

Any questions? Or wondering what it is like to, work at Radboudumc? Then sent an email to Prof. Dr. Peter Friedl , Full Professor. Use the Apply button to submit your application.

Additional comments

Any questions? Or wondering what it is like to, work at Radboudumc? Then sent an email to Prof. Dr. Peter Friedl , Full Professor. Use the Apply button to submit your application.

Website for additional job details

https://www.academictransfer.com/337617/

Work Location(s)

Number of offers available

1

Company/Institute

Radboudumc

Country

Netherlands

City

Nijmegen

Postal Code

6525 GA

Street

Geert Grooteplein-Zuid 10

Geofield

Where to apply

Website

https://www.academictransfer.com/en/337617/phd-candidate-cancer-metastasis-and-…

Contact

City

Nijmegen

Website

http://www.radboudumc.nl/

Street

Geert Grooteplein-Zuid 10

Postal Code

6525 GA

STATUS: EXPIRED