PhD candidate 'Advancing Hemostasis Research through Novel Assays and Integrative Approaches'

6 Feb 2024
Job Information

Organisation/Company

Radboud University Medical Center (Radboudumc)

Research Field

Medical sciences
Physics

Researcher Profile

First Stage Researcher (R1)

Country

Netherlands

Application Deadline

22 Feb 2024 - 23:00 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

38.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Synapse Research Institute and the Laboratory of Hematology of the Radboudumc collaborate in the field of thrombosis and hemostasis. Hemostasis is a tightly regulated system, and a disbalance in this system can cause thrombosis on one side, whereas bleeding can occur on the other. Both of these pathological processes can lead to serious complications, morbidity and mortality.

In this specific PhD project, a novel hemostasis assay (plasmin generation) will be validated in vitro in coagulation factor deficient plasma and in three distinct patient groups from the Hemophilia Treatment Center of the Radboudumc. As a PhD candidate you will define and analyze essential laboratory characteristics of thrombin generation and plasmin generation tests and will integrate these assays together with diagnostic tests through dynamic modelling and Artificial Intelligence. The ultimate goals is to better predict the bleeding phenotype of these patients and improving patient care.

You will be working together in a team with a colleague (clinical) PhD student in order to clinically validate these tests, and with private (Synapse) as well as public (Radboudumc) partners. You will be appointed at the Synapse Research Institute, you will be situated at the Radboudumc.

Tasks and responsibilities

• Analysis of thrombin and plasmin generation.
• Develop and validate thrombin and plasmin dynamics analysis.
• Conduct systematic searches in literature databases.
• Writing scientific publications for international journals.
• Presenting results at (scientific) meetings.
• Collaborating with promoters, supervisors and internal and external partners.
• Participate in education.

In addition, PhD students contribute to general scientific activities taking place within the laboratory of hematology and within the research institute.

Requirements
Specific Requirements

You are a PhD candidate with a keen interest in hemostasis and laboratory testing. You have the ambition to pursue the application of diagnostic opportunities to improve patient care. You are also proactive in your efforts to approach this research project from multiple angles, and you have excellent communication skills to establish (novel) cooperations as well as eminent writing skills to communicate your findings with the (academic) society.

Moreover you have:

• Finished a master in Biochemistry, Molecular Biology, Molecular Life Sciences, Biomedical Sciences or a related master.
• Experience in molecular biology, pathobiology, analytical chemistry, bioinformatics.
• Languages: preferably fluent in Dutch and English.

Additional Information
Benefits

Starting date is April 1st 2024. You will be appointed at the Synapse Research Institute, you will be situated at the Radboudumc.

As an employer, we believe that employees should feel vital and happy at work in all stages of life. We are also committed to creating a healthy and safe working environment. Our employment conditions contribute to that. What we offer:

• Upon commencement of employment, you will start at scale 10A, step 0 (€2,901 based on a full-time appointment). Over a maximum period of 4 years, you will progress to scale 10A, step 3 (€3,677 based on a full-time appointment). You will also receive an 8% holiday allowance, an 8.3% end-of-year bonus, and a 47% to 72% bonus for working unsocial hours.
• Plenty of opportunities for personal development. You can take a variety of courses in our online learning environment. You can also share knowledge with colleagues through digital learning spaces – perfect for getting inspired and inspiring others.
• Your well-being and vitality are our priorities. For instance, you can enjoy a 40% discount on a sports subscription at the Radboud Sports Center along with access to the Healthy Professionals program designed to assist you in managing your energy. If you are going through a life-changing event, our Company Support Team and a personal coach are there to help you.
• Support in achieving a good work-life balance at every stage of your life. This includes advice and training courses (from ‘Millennial Dilemmas’ to ‘Your Career After 57’), activities at our own mindfulness center , and informal caregiving consultations if you have questions about juggling work and caregiving responsibilities at home.
• 224 holiday hours per year based on a 38-hour working week. The option of taking national holidays at other times of the year.
• 26 weeks of parental leave, nine of which are paid.
• An allowance for your travel expenses.

Selection process

Any questions? Please contact Sanna Rijpma , PhD EuSpLM via +31 6 31 01 51 92, An Stroobants , PhD EuSpLM via +31 6 31 14 74 10, Saskia Schols , PhD, MD or Bas de Laat . Use the Apply button to submit your application.

Additional comments

Any questions? Please contact Sanna Rijpma , PhD EuSpLM via +31 6 31 01 51 92, An Stroobants , PhD EuSpLM via +31 6 31 14 74 10, Saskia Schols , PhD, MD or Bas de Laat . Use the Apply button to submit your application.

Website for additional job details

https://www.academictransfer.com/337396/

Work Location(s)

Number of offers available

1

Company/Institute

Radboudumc

Country

Netherlands

City

Nijmegen

Postal Code

6525 GA

Street

Geert Grooteplein-Zuid 10

Geofield

Where to apply

Website

https://www.academictransfer.com/en/337396/phd-candidate-advancing-hemostasis-r…

Contact

City

Nijmegen

Website

http://www.radboudumc.nl/

Street

Geert Grooteplein-Zuid 10

Postal Code

6525 GA

STATUS: EXPIRED