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to disease models; Align these findings with human disease. Requirements Specific Requirements You have a master's degree in a field related to biomedical sciences, (medical) biology, biochemistry
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your findings in an array of cellular iPSC-models present in the lab, compare these to known iPSC- and human patient datasets and define a mechanism of action. You will then work with an (inter)national
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applicants for a PhD position in Stem cells and Multiple Sclerosis (MS). Your work will focus on human iPSC-based models of inflammation and MS to study microglial cell functioning in a white matter- and grey
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human iPSC derived retinal GACR models and perform tailored therapeutic screens with repurposed medicine taken from the parallel SYMPATHIC consortium (Karnebeek and coworkers 2023). The candidate will
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these findings with human disease. Requirements Specific Requirements You have a master's degree in a field related to biomedical sciences, (medical) biology, biochemistry or bioinformatics; You have experience in
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this collaborative project, we will investigate the mechanisms of tRNA gene regulation using novel methods and technologies in human cells and budding yeast. We will take advantage of CRISPR-mediated approaches, high
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. Both labs have complementarity tools to tackle this novel hypothesis. The van Baarsen lab has access to unique human samples, and the van Egmond lab recently created novel mouse models. By studying
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to different receptors; Study the capacity of nanobodies to block infection by pathogens and develop and test nanobody based vaccines using human in vitro culture systems; Work closely with our collaborators
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pharmacokinetics/pharmacodynamics (PKPD) modeling, we will then establish the relationship between exposure and response. The goal is to develop a model-informed precision dosing tool, which will optimize
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scientific papers which will form the basis of your PhD thesis. Requirements Specific Requirements You must have a professionally relevant background in system science, human movement science, epidemiology