IIT invites excellent candidates to apply to its PhD program organized in collaboration with the Open University; this international PhD program confers Doctorates in Health, Sustainable and Human Technologies.
In order to be admitted into the ARC program, the minimum requirements are
i. a Masters-level degree, which broadly corresponds to a 4/5-year undergraduate MSc/MChem/Meng-style degree or to a postgraduate Masters in the British system, or to a second level University degree in Italy;
ii. a grade corresponding to an upper second class (2.1) or a merit in the UK system or 100/110 in the Italian system. Candidates with lower grades but redeeming features (publications, specific expertise) are requested to contact the potential supervisors before applying;
iii. where English is not the applicant’s first language, a valid IELTS (International English Language Testing System) certificate. The minimum acceptable score is an overall 6.5, with no less than 6.0 in any of the four categories
One PhD fellow position will be available from October 1st 2022 in the Integrative Nuclear Architecture Research Line, led by its Principal Investigator, Irene Farabella.
Title of the project: Genome structural plasticity: tools for single-cell spatial genomics analysis and quantification
Background: Spatial genomics techniques (Bintu, Mateo et al. 2018, Nir, Farabella et al. 2018, Szabo, Jost et al. 2018, Finn, Pegoraro et al. 2019, Su, Zheng et al. 2020, Takei, Yun et al. 2020) enable the direct visualisation of multiple genomic loci in the nuclear space allowing the investigation of the properties of the chromatin fiber over a range of length-scales (ranging from kilobases to multiple megabases in length) one cell at the time. However, in addition to the direct visualisation of the 3D genome at varied scale and resolutions, there is a need for standardised quantitative ad-hoc analysis methods and for method to integrate spatial genomics data with others genomics information to shed light on the relationship between genome structural plasticity and genome function.
Description: We are looking for a motivated PhD student with an enthusiasm to develop and implement tools to investigate the single-cell genome structure at nanoscale. Our research uses hybrid method (computational and experimental) integrating imaging techniques, as seq-OligoSTORM(Nir, Farabella et al. 2018), genomic data, structural bioinformatics, and physical theories for determining the 3D structures of genome that will contribute to a more complete characterization of genome regulatory circuits. The successful candidate will be involved in the design, development and implementation of computational tools for spatial genomic analysis and modelling. The candidate will interact and collaborate closely with other researchers in the Farabella Lab as well as with members of the other research groups within the CHT.
References:
Bintu et al., Science (2018) 362(6413).
Finn et al., Cell (2019) 176(6): 1502-1515 e1510.
Nir, G., I. Farabella, C. Perez Estrada, C. G. Ebeling, et al., PLoS Genet (2018) 14(12): e1007872.
Su et al., Cell (2020) 182(6): 1641-1659.e1626.
Szabo et al., Sci Adv (2018) 4(2): eaar8082.
Takei et al., Nature (2020) 590(7845): 344–350.
Main Supervisor: Irene Farabella (Integrative Nuclear Architecture)
Essential expertise:
i. Genetics/biology/bioinformatics/theoretical physics background or closely related fields
ii. Good proficiency in Python
iii. Familiarity with 3D biomolecules
iv. Proficiency with Unix/Linux operating system
Desirable expertise:
i. Familiarity with imaging technologies, processing and analysis
ii. Familiarity with genomic data.
iii. Familiarity in machine learning, statistics, optimization.
iv. Familiarity with molecular modelling tools
How to apply. Prospective students must submit using the online form the following documents
1) 2-page CV, which includes studies, expertise and achievements.
2) 1-page research statement, which includes the choice of a project from the list above and a justification of the choice. Only if robustly justified, the student may signal their interest also for a second project, but there is no guarantee that this will be taken into account by the selection panel.
3) A transcript of undergraduate and postgraduate studies.
4) A valid IELTS certificate, obtained no more than two years before the proposed registration date.
5) Contact details of two referees.
For this position, ARC accepts candidatures on an ongoing basis (first-come, first-served).
Printable version: HERE
Istituto Italiano di Tecnologia, with its headquarters in Genoa, Italy, is a non-profit institution with the primary goal of creating and disseminating scientific knowledge and strengthening Italy's technological competitiveness. IIT's research endeavour focuses on high-tech and innovation, representing the forefront of technology with possible application from medicine to industry, computer science, robotics, life sciences and nanobiotechnologies.
Istituto Italiano di Tecnologia is an Equal Opportunity Employer that actively seeks diversity in the workforce.
Please note that the data that you provide will be used exclusively for the purpose of professional profiles’ evaluation and selection, and in order to meet the requirements of Istituto Italiano di Tecnologia. Your data will be processed by Istituto Italiano di Tecnologia, based in Genoa, Via Morego 30, acting as Data Controller, in compliance with the rules on protection of personal data, including those related to data security.
Similar Positions
-
Ph D Bioinformatics Student Sloppiness In M Rna, AcademicTransfer, Netherlands, about 5 hours ago
The research group of Reuven Agami at the division of Oncogenomics at the Netherlands Cancer Institute in Amsterdam has recently uncovered a novel phenomenon in cancer termed “Sloppiness”. They sh...
-
Ph D Student Position In Blood Cancer Research , University of Basel, Switzerland, 22 days ago
The Department of Biomedicine (DBM) is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of he...
-
Ph D Student In Vascular Cell Biology/Immunology, Leiden University, Netherlands, 6 days ago
Apply now The Faculty of Science and the Institute for Biology Leiden are looking for an: PhD student in vascular cell biology/immunology Key responsibilities The PhD student will work in close co...
-
Multiple Ph D Positions On "Single Cell Proteome Profiling" , ETH Zurich, Switzerland, about 19 hours ago
100%, Zurich, fixed-term The laboratory of Single-Molecule and Single-Cell Biophysics (BMC) is a research group in the Department of Information Technology and Electrical Engineering (D-ITET) at E...
-
Ph D Student In Vascular Cell Biology/Immunology, AcademicTransfer, Netherlands, 25 days ago
PhD student in vascular cell biology/immunology PhD student in vascular cell biology/immunology Published Deadline Location today 21 Apr Leiden The Faculty of Science and the Institute for Biology...
-
Ph D Student: Machine Learning In Plant Regulatory Genomics, VIB, Belgium, about 19 hours ago
Job description The Vandepoele research lab (Comparative Network Biology - https://www.vandepoelelab.be/ ) invites applications for a fully-funded PhD project for 1 year and extended with another...