Marie Skłodowska-Curie Doctoral Network NANOREMEDI-programme in “Functional Nano-Scaffolds for Regenerative Medicine” stems from six Doctoral Courses/Schools at six beneficiary institutions, providing research and training in the field of nanomaterials for Regenerative Medicine. An active contribution of enterprises in training activities is a relevant feature of the programme.
Beneficiaries (Doctorate Courses/Schools): University of Milan (Pharmaceutical Sciences), ITALY – Coordinating University; Universitat Politècnica de Catalunya (Polymers and Biopolymers) SPAIN; The Hebrew University Jerusalem (School of Chemistry), ISRAEL; Université de Montpellier (Balard Chemical Sciences doctoral school), FRANCE; University of Pavia (Bioengineering, Bioinformatics & Health Technologies), ITALY; IC nanoGUNE (Materials Physics; delivered by University of the Basque Country - Associated Partner linked to NANOGUNE beneficiary), SPAIN.
Associated partners for secondments activities: Bayer Health Care Pharmaceuticals – ITALY; Edelweiss Connect GMBH – SWITZERLAND; Italfarmaco S.p.A. (CHEMI) – ITALY; Jacobacci & Partners – ITALY; Lynxter -FRANCE; Simune Atomistics SL – SPAIN; Ponti & Partners, SLP – SPAIN; AbMedica – ITALY; DeLama – ITALY; Officine Innovazione Srl (Deloitte) – ITALY; Genepep – FRANCE; BioBasic Europe rsl - ITALY
The scientific approach proposed by NanoReMedi Consortium is strongly multidisciplinary and will involve a number of different state-of-the-art technologies and methodologies. Expected results are:
- Generate tissue engineered vascular grafts (VGs) to replace damaged peripheral arteries
- Study stem-cell based regenerative medicine for bone and cartilage repair
- Tackle implantation failure of engineered tissues/scaffolds
13 ESR PhD positions are offered by the Consortium related to different and multidisciplinary projects strongly interconnected involving different state-of-the-art technologies and methodologies: Computational chemistry; Chemical synthesis/peptide synthesis; Peptide based Nanomaterials (Soft materials/Hydrogels/Electrospinning) preparation and spectroscopic characterization; Production of vein graph; 3D-tissue fabrication; Biofilm prevention; Electrostimulated release of antimicrobial peptides
Each ESR will attend the following training activities: i) advanced courses and soft and transferable skill courses provided by University’s doctorate courses/schools; ii) multidisciplinary courses/Summer delivered by NanoReMedi Network at the general Network Meetings/; iii) Nine-months secondment at one of the Beneficiary jointly awarding the doctoral degree to improve research methods complementary to those at home institution; iv) Three-months secondment at one of the enterprise where ESRs are expected to acquire complementary skills.
Job Summary (Fabrication of off-the-shelf biodegradable small calibre vascular grafts (VGs) with improved microbiological and regenerative features)
1. Testing fibres formation by electrospinning of: i) DOPA-Phe-Phe-RGD; ii) selected newly-synthetized peptides functionalized with DOPAPhe-Phe-RGD and fluorinated AAs. 2. Evaluation of the contribution of compatible adjuvant polymers (i.e. PLA or PLA-PCL) to DOPA-Phe-Phe-RGD-/fluorinated AAs-peptides derivatives on fibres formation. 3. Bi/multi-layered composite flat scaffolds preparation by eletrospinning. 4. Morphological, mechanical, biological and microbiological characterization of the composite flat grafts. 5. Composite small calibre VGs preparation and their morphological, mechanical, physical-chemical and biological characterization. Stability and sterilization studies will be also performed.
One position is available at University of Pavia in research project ESR9:
Secondments: i) nine months at The Hebrew University Jerusalem (School of Chemistry, ISRAEL): Microbiological tests on electro-spun flat grafts for evaluating the PBC efficacy to prevent bacterial contamination; ii) three months of enterprise secondment at De Lama S.p.A. (ITALY): to gain specific expertise on sterilization with Hydrogen Peroxide under deep vacuum and zero air.
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