Enzyme Technology Lab of the Department of Chemistry is active on the
field of biocatalysis and biotransformations. CEPOPA project, which is
funded from H.F.R.I. (Greece), aims the development of novel
chemoenzymatic processes for the synthesis of optically pure amines,
compounds with possible pharmaceutical interest. More specifically, it
focuses on the combination of two incompatible reactions: The chemical
oxidation of alcohols and alkynes from nanomaterials and the enzymatic
enantioselective amination of ketones from transasminases. During
CEPOPA, enzymes will be immobilized onto functional nanomaterials, in
order to enable the process to be performed one-pot and the
applicability will be showcased with specific substrates. In the
framework of CEPOPA project, two young scientists will be trained.
Main role of this position will be the organic sythesis and
characterization. The selected candidate will undertake the synthesis
and characterization of graphene oxide and other redox nanomaterials
that can be used as immobilization matrix. Later, the candidate will
work on transaminase immobilization on selected nanomaterials and their
The deliverables linked to this position are related to the protocol of
synthesis of the desired nanomaterial with high catalytic potential, as
well as the catalytic characterization of the most prominent
nanomaterials. Moveroever, the optimized protocol of transaminase
immobilization onto these nanomaterials will be delivered, among with
some quantity of the bioconjugate and a report on the structure-fuction
of the immobilizate. Finally, the candidate will have to aid the writing
of the annual reports, publications and conference proceedings.
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