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embeddings, genetic variation (e.g. pQTLs) and experimental perturbation data, rather than relying on curated pathway databases (e.g. KEGG, Reactome) that introduce a human bias. The successful candidate may
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sufficient to accelerate aging. Conversely, genetic or pharmacological enhancement of proteostasis network capacity can extend lifespan and suppresses age-related disease associated with protein misfolding
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sediments. Through laboratory enrichment and stable isotope probing experiments, we have already identified several key microorganisms; however, their genetic potential and specific functions remain
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in the elderly population, and its pathological mechanisms are complex and not fully understood. In human patients, the elevated systemic levels of five factor H-related proteins (FHRs1-5) have been
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Deutsches Zentrum für Neurodegenerative Erkrankungen | Bonn, Nordrhein Westfalen | Germany | 2 months ago
Neurology Research Group investigates glymphatic influx and efflux pathways during physiological ageing and neurodegenerative disease, with a particular focus on how genetic and environmental risk factors
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German Cancer Research Center in the Helmholtz Association (DKFZ) | Oettingen in Bayern, Bayern | Germany | about 2 months ago
to create a space where scientific discovery in cancer research is transformed into benefits for human health. Together with selected university partner sites, the DKFZ has established the German Cancer
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to contribute to a better understanding of the development and progression of neurodegenerative diseases. Job Description Analyze alterations in RNA regulation in the human brain using single-cell transcriptomics
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mechanisms. The planned project will use a broad range of technologies, including genetics, imaging, biochemistry, molecular biology, enzymology, cell culture and experimental animal models (mice and zebrafish
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German Cancer Research Center in the Helmholtz Association (DKFZ) | Heidelberg, Baden W rttemberg | Germany | 2 months ago
to create a space where scientific discovery in cancer research is transformed into benefits for human health. The Junior Research Group "Brain Mosaicism and Tumorigenesis" headed by Dr. Pei-Chi Wei is
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German Cancer Research Center in the Helmholtz Association (DKFZ) | Oettingen in Bayern, Bayern | Germany | 3 months ago
to create a space where scientific discovery in cancer research is transformed into benefits for human health. Together with selected university partner sites, the DKFZ has established the German Cancer