Postdoctoral Position in Nanobody Discovery

Updated: about 2 hours ago

Background:
Binders, such as antibodies, are indispensable research tools for the detection and manipulation of proteins, yet antibodies with the desired specificity and affinity are often not available. This is especially true for compact membrane transporters like the Solute Carrier families. Research in the Geertsma lab focuses on the development of nanobodies as enabling technology for our studies on Solute Carriers [1-4]. As part of the DFG Research Unit FOR5046 that will perform an integrated analysis on anion transporters of the Solute Carrier family 26 (SLC26), the successful candidate will generate camelid single-domain antibodies (nanobodies and synthetic nanobodies) for imaging and modulation of protein activities.

Your qualifications:
Candidates should have a PhD degree in biochemistry, molecular biology, biotechnology or a related field. Strong experience in display technologies (such as phage display or ribosome display), molecular cloning (e.g., the generation of immune or synthetic libraries), and the biophysical characterization of protein-protein interactions (SPR, ITC, DSF, etc.) is highly desirable. Experience in (membrane) protein production and purification, directed evolution, and computational analysis of antibody sequences would be an advantage. The successful candidate holds strong troubleshooting skills and efficiently interacts with members of an interdisciplinary team of cell biologists, biochemists, and clinicians, can work in a competitive international environment, and possesses excellent English communication skills (written and oral).
[1] Zimmermann et al., Nat Protoc, 15(5):1707-1741 (2020)
[2] Zimmermann et al., Elife, 7:e34317 (2020)
[3] Schenck et al., Biochemistry, 56(30):3962-3971 (2017)
[4] Geertsma et al., Nat Struct Mol Biol, 22(10):803-9 (2015)

Our offer:
This full-time position is available immediately and applications will be reviewed on receipt. This position is affiliated to a 3-year DFG grant part of Research Unit FOR5046 on the Integrated analysis of epithelial SLC26 anion transporters - from molecular structure to pathophysiology. We especially encourage women to apply.

For further information contact Dr. Eric Geertsma by email geertsma mpi-cbg.de

The Max Planck Society strives for gender and diversity equality. We welcome applications from all backgrounds.

Please submit your complete application and CV including a full publication list, a cover letter stating your motivation to apply for this position, a brief description of your research interests and accomplishments together with contact details of at least two referees as a single pdf file by May 23rd, 2021 stating Code 2021-PostDoc-4050 via our online application system at
https://recruitingapp-2443.umantis.com/Vacancies/452/Application/CheckLogin/2?lang=eng

Max Planck Institute of Molecular Cell Biology and Genetics
Pfotenhauerstr. 108, 01307 Dresden, Germany
http://www.mpi-cbg.de


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