PhD student (m/f/d) Research Group Translational Cardiovascular Genomics at the Department of Cardiology

10.08.2022, Wissenschaftliches Personal

The German Heart Center of the Free State of Bavaria associated to the Technical University of Munich is a clinic with international reputation and a state of the art technical and medical equipment. The Research Group Translational Cardiovascular Genomics (Principal Investigator: Thorsten Kessler, MD) at the Department of Cardiology is seeking a PhD student (m/f/d) The research group of Dr. Thorsten Kessler is looking to recruit a highly motivated PhD student to join a dynamic international research team at the German Heart Center Munich, Department of Cardiology. Our research focusses on the role of genetic risk factors in cardiovascular diseases and vascular biology. We use state-of-the-art molecular biology, OMICs, and transgenic mouse model approaches to gain novel mechanistic insights. Ultimately, our goal is to develop unprecedented therapeutic concepts to prevent and treat atherosclerosis and myocardial infarction. We are part of the collaborative research center SFB 1123 “Atherosclerosis - Mechanisms and Networks of Novel Therapeutic Targets” and the Munich Heart Alliance within the German Center for Cardiovascular Research (DZHK). Our research is funded by the German Research Foundation (DFG: SFB 1123, project B2; research grant KE 2116/4-1), the German Center for Cardiovascular Research and the Corona Foundation (Corona-Stiftung im Stifterverband).

Profile/Requirements:
- Excellent command of molecular biology and interest in transgenic animal experiments
- Interest in the application of single cell sequencing and deep visual proteomics technologies
- Interest in cardiovascular research
- Accuracy and reliability, initiative, organisational skills and a high sense of responsibility
- Very good written and spoken English
- High level of communication skills
- Ability to work in a team

Recent publications:
-Colchicine impacts leukocyte trafficking in atherosclerosis and reduces vascular inflammation.

Meyer-Lindemann U, Mauersberger C, Schmidt A-C, Moggio A, Hinterdobler J, Li X, Khangholi D, Hettwer J, Gräßer C, Dutsch A, Schunkert H, Kessler T*, Sager HB*

Front Immunol, 2022 (IF=7.6)

Interleukin-1β suppression dampens inflammatory leukocyte production and uptake in atherosclerosis.

Hettwer J, Hinterdobler J, Miritsch B, Deutsch MA, Li X, Mauersberger C, Moggio A, Braster Q, Gram H, Robertson AAB, Cooper MA, Groß O, Krane M, Weber C, Koenig W, Soehnlein O, Adamstein NH, Ridker P, Schunkert H, Libby P, Kessler T*, Sager HB*

Cardiovasc Res, 2022 (IF=13.1)

Identification of a functional PDE5A variant at the chromosome 4q27 coronary artery disease locus in an extended myocardial infarction family.

Dang TA*, Kessler T*, Wobst J, Wierer M, Braenne I, Strom TM, Tennstedt S, Sager HB, Meitinger T, Erdmann J, Schunkert H

Circulation, 2021 (IF=39,9)

A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy.

Wierer M, Werner J, Wobst J, Kastrati A, Cepele G, Aherrahrou R, Sager HB, Erdmann J, Dichgans M, Flockerzi V, Civelek M, Dietrich A, Mann M, Schunkert H, Kessler T

Eur Heart J, 2021 (IF=35,9)

Coronary artery disease genetics enlightened by genome-wide association studies.

Kessler T, Schunkert H

JACC Basic Transl Sci, 2021 (IF=9,5)

Functional investigation of the coronary artery disease gene SVEP1.

Winkler MJ, Müller P, Sharifi AM, Wobst J, Winter H, Mokry M, Ma L, van der Laan SW, Pang S, Miritsch B, Hinterdobler J, Werner J, Stiller B, Güldener U, Webb TR, Asselbergs FW, Björkegren JLM, Maegdefessel L, Schunkert H, Sager HB, Kessler T

Basic Res Cardiol, 2020 (IF=17,2)

Our offer:
- An employment contract initially limited to three years with longer-term prospects
- Remuneration according to TV-L E13 (65%) (incl. annual bonus)
- Attractive employer offers (e.g. sports programme, staff restaurant, staff sales in the hospital pharmacy)

The German Heart Center Munich promotes professional equality between women and men and provides the same employment opportunity for severely disabled people in case of equal qualifications.

Contacts:
- Thorsten Kessler, MD, Principal Investigator, telephone +49 89 1218 2786
- Michaela Frint, project manager, telephone +49 89 1218 1764
- Thomas Schmid, Head of Recruiting/HR, telephone +49 89 1218 1734

Your application should include:
- Cover letter describing your research interest and why you are suitable for the position (maximum 1 page)
- CV including a list of relevant publications
- Copy of the official academic transcript of your degree or a letter stating when your degree will be obtained
- Names, e-mail addresses, and telephone numbers for academic references/recommendation letters

Please send us your application until September 30th, 2022 by E-Mail to: [email protected]
Interview expenses will not be reimbursed.

Data Protection Information:
When you apply for a position with the Technical University of Munich (TUM), you are submitting personal information. With regard to personal information, please take note of the Datenschutzhinweise gemäß Art. 13 Datenschutz-Grundverordnung (DSGVO) zur Erhebung und Verarbeitung von personenbezogenen Daten im Rahmen Ihrer Bewerbung. (data protection information on collecting and processing personal data contained in your application in accordance with Art. 13 of the General Data Protection Regulation (GDPR)). By submitting your application, you confirm that you have acknowledged the above data protection information of TUM.

Kontakt: Herr Schmid, Personalgewinnung, Telefon-Nr. (089) 1218-1734; E-Mail-Adresse: [email protected]

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