PhD student (m/f/d) for a project funded by the SFB 1190, "Compartmental Gates and Contact Sites in Cells"

Updated: about 1 month ago

The laboratory of Prof. Fernandez-Busnadiego at the Institute of Neuropathology, University Medical Center Göttingen, is offering a position for:


The goal of the Fernandez-Busnadiego lab is to unravel the structural basis of fundamental cellular mechanisms, as well as their alterations in human disease. To that end, we employ multidisciplinary approaches, pivoting on state-of-the art cryo-electron tomography (see e.g. Bäuerlein et al., Cell 2017 (https://www.ncbi.nlm.nih.gov/pubmed/28890085); Guo et al., Cell 2018 (https://www.ncbi.nlm.nih.gov/pubmed/29398115); Collado et al., Dev Cell 2019 (https://pubmed.ncbi.nlm.nih.gov/31743662/); Trinkaus et al., biorxiv 2020 (https://www.biorxiv.org/content/10.1101/2020.08.07.234138v1) click here (https://www.ncbi.nlm.nih.gov/pubmed/?term=Fern%C3%A1ndez-Busnadiego%20R%5BAuthor%5D&cauthor=true&cauthor_uid=29398115) for a complete publication list).

The lab is integrated in the Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable cells" (MBExC). MBExC is an interdisciplinary, cross-faculty research center of the University of Göttingen and pursues a novel research approach with joint efforts in modern bioimaging, in particular photonics, molecular biosciences, neuroscience and cardiovascular research.  The goal of MBExC is to decipher disease relevant nanoscale functional units in neurons, sensory cells and cardiomyocytes with the long-term goal to develop innovative therapeutic strategies for disorders affecting the heart and the brain, or both.

The successful candidate will work on revealing the mechanisms by which membrane curvature contributes to lipid homeostasis in the cell (Collado et al., Dev Cell 2019). To that end, in vitro reconstitutions and in vivo mutagenesis in yeast will be combined with cryo-electron tomography imaging. The project will be integrated into the Collaborative Research Center SFB1190, a Göttingen-based consortium of groups studying membrane contact sites and compartmental gates from a highly multidisciplinary perspective.

We are looking for a highly motivated candidate with a M.Sc. in Biology or related disciplines and strong practical experience in biochemistry/cell biology. Practical experience in microscopy/structural biology is highly desired.

Applications should include a motivation letter, CV and the contact details of at least two referees. They should be sent by email to Prof. Fernandez-Busnadiego at ruben.fernandezbusnadiego@med.uni-goettingen.de.

For further information or any further inquiry, please also send to the above address.


Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.

Please send your application only via e-mail as a PDF-file.


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