PhD student (f/m/x) – Code 1195/2023/3PhD - Individual Supervisor

The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine. www.dzne.de

The DZNE in Bonn advertises a position as

PhD student (f/m/x) – Code 1195/2023/3

with a focus on disease mechanisms of self-templating protein aggregates.

The laboratories led by Prof. Ina Vorberg and Prof. Markus Zweckstetter study molecular and cellular mechanisms of protein misfolding. In a collaborative project, we investigate the impact of small molecules on liquid-liquid phase separation of the Alzheimer disease-related protein Tau in vitro and in Tau biosensor cells. To this end, we perform biophysical, biochemical and cell biological analyses and use state-of-the-art technology such as automated image-based high content screening.

The research of the candidate will include the development of cell-based assays and high content screens using selected compound libraries. We are looking for a PhD student with excellent practical and theoretical skills and a strong interest in cell biological aspects of neurodegenerative diseases and drug development. The successful applicant should hold a Master’s degree in cell biology or related fields. Experience in research on neurodegenerative diseases, viral vectors, cell-based screening assays and/or image analysis would be an advantage. The candidate should be able to work independently and have excellent team working skills. A written and oral command of English is essential.

We offer

·         A highly relevant research topic

·         A cutting-edge infrastructure

·         An international environment and excellent working conditions

• Employment, payment and social benefits are consistent with those at other research institutes

·         A full-time position, available initially for 3 years with the possibility of an extension.

You will obtain special skills and knowledge for your scientific qualification during your activities at DZNE. The DZNE is an equal opportunity employer. It especially welcomes and encourages disabled individuals to apply.

Interested candidates should send their application (including CV, sample of publications, a summary of research interests and three references) as a single pdf file via the following link: https://jobs.dzne.de/en/jobs/101139/form