PhD student (Dr. rer. nat.) (f/m/d)

The Department of Molecular Oncology University Medical Center Göttingen is looking as of 1st September 2022 for a

About us

Our research group within the Department of Molecular Oncology is applying cancer therapeutics as well as antibodies for the treatment of virus infections, in particular to interfere with the replication of SARS- CoV-2. We are now seeking a strong candidate to further evaluate these approaches and to identify druggable steps in the virus replication cycle.

Selected References:

Stegmann KM, Dickmanns A, Heinen N, Blaurock C, Karrasch T, Breithaupt A, Klopfleisch R, Uhlig N, Eberlein V, Issmail L, Herrmann ST, SchreieckA, Peelen E, Kohlhof H, Sadeghi B, Riek A, Speakman JR, Groß U, Görlich D, Vitt D, Müller T, Grunwald T, Pfaender S, Balkema-Buschmann A, and Dobbelstein M. (2022) Inhibitors of dihydroorotate dehydrogenase cooperate with Molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication. iScience 10.1016/j.isci.2022.104293

Güttler T, Aksu M, Dickmanns A, Stegmann KM, Gregor K, Rees R, Taxer W, Rymarenko O, Schünemann J, Dienemann C, Gunkel P, Mussil B, Krull J, Teichmann U, Groß U, Cordes VC, Dobbelstein M*, Görlich D*. (2021) Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation- tolerant nanobodies. EMBO J. 40(19):e107985. doi: 10.15252/embj.2021107985. *co-corresponding authors

Stegmann KM, Dickmanns A, Gerber S, Nikolova V, Klemke L, Manzini V, Schlösser D, Bierwirth C, Freund J, Sitte M, Lugert R, Salinas G, Görlich D, Wollnik B, Groß U and Dobbelstein M. (2021) The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models. Virus Research 302, 198469

Your Qualifications:

The successful candidate will hold a Master of Science degree in the biosciences with a background in virology, or alternatively in cell biology and related subjects. Experience in cell culture techniques, molecular biology, microscopy and/or sequence analysis would be desirable. The ideal candidate has already performed virus research, but we do consider committed candidates from outside this field.

We offer:

• Research projects funded by the Coronavirus Research Network Niedersachsen (COFONI) and by the Volkswagenstiftung, providing an active and collaborative network of researchers
• A friendly, supportive and skilled team
• Proper guidance in shaping your research project
• An extensive range of research training courses
• Opportunities of presenting your science on international meetings
• Salary according to the collective agreement for the public State service (TV-L) including social benefits

The University Medical Center Göttingen is committed to professional equality. We therefore seek to increase the proportion of under-represented genders. Applicants with disabilities and equal qualifications will be given preferential treatment.

We look forward to receiving your application by 15.07.2022:

University Medical Center Göttingen

Department of Molecular Oncology

Prof. Dr. Matthias Dobbelstein

Director

Justus-von-Liebig-Weg 11

37077 Göttingen

Tel.: 0551/39-60757

Contact person: Please send your applications exclusively to: Frau Heike Voigt / phone: 0551/39-60763 / E-Mail: [email protected]

Please send your application only via e-mail as a PDF-file.

Travel and application fees cannot be refunded or transferred.