PhD Position in Pathophysiology and Treatment of Diabetes Focusing on the Role of TRP Channels (m/f/x)PhD - Individual Supervisor

Two billion adults and forty million children are currently overweight with 350 million afflicted with diabetes. Most people with excess body weight have proven largely resistant to weight loss by current therapeutic approaches. Therefore, the development of safe and effective drug therapy to complement healthy lifestyle intervention is a global priority. One of the major goals in the diabetes research field and drug development for this disease is to identify the factors that regulate β‐cell function and influence insulin secretion. New research has shown the expression of several TRP channels in pancreatic β-cells. It has been suggested that TRP channels are important regulators of insulin secretion. However, the exact role of several TRPs such as TRPM5 and TRPM7 in insulin secretion, glucose homeostasis and the development of diabetes has not yet been determined. Here, we use various transgenic mouse models in order to identify those channels that particularly regulate insulin secretion and insulin production in pancreatic β‐cells. Furthermore, we study the function of TRP channels during periods of metabolic stress, such as high fat diet‐induced obesity.

We are looking for a highly motivated Biologist, Cell Biologist or Biochemist with a Master in Science, interested in learning pancreatic islet research and metabolic phenotyping of the transgenic mice as part of the PhD studies. As part of an international group, the candidate should feel comfortable speaking and writing in English, be open minded, and feel enriched when exposed to cultural differences.

In addition, the PhD candidate should:

•             have laboratory experience, preferably working in sterile conditions and cell culture,

•             have experience working with mice, preferably with certificate (LAS interactive),

•             enjoy teaching,

•             have a curious and analytical mind.