To strengthen our team, we are offering a
h3. *Ph.D. position in computational biology or bioinformatics*
We are looking for a computational biology/bioinformatics Ph.D. student to process and analyze next-generation sequencing data to understand the functional contributions of the non-coding genome in the cardiovascular system.
*About the lab*
We bridge computational and experimental strategies to understand the functional contributions of the non-coding genome, such as regulatory DNA elements and long non-coding RNAs (lncRNAs) in the cardiovascular system. We aim to understand the impact of epigenetic changes on heart function and explain why there is a gender bias for cardiovascular disease. More specifically, we will use mouse models and patient-derived samples to study the impact of epigenetic changes on female X chromosome inactivation and genomic imprinting. Furthermore, we aim to elucidate relevant therapeutic candidates and new non-coding regulatory regions-based disease mechanisms that may form the basis of new therapies.
*About the institute*
The Institute of Pharmacology and Toxicology (IPT) is part of the Medical Faculty of the Technical University of Munich (TUM), one of the leading universities in the European Union. The institute's research focuses on non-coding RNAs, their control of cardiac gene expression, and the effects of their therapeutic manipulation in cardiac disease. The institute's state-of-the-art research facility includes a fully equipped mouse cardiac phenotyping lab, a viral vector core, and the entire experimental pipeline for next-generation sequencing from tissue or single-cells, including FACS-based cell separation. Furthermore, the IPT coordinates and receives funding from the DFG Collaborative Research Center TRR267 "Non-coding RNA in the Cardiovascular System" and is the Munich partner site of the German Center for Cardiovascular Research (DZHK). The outstanding infrastructure and experience present in the institute provide an ideal environment for a project to succeed.
* Preferably, you hold a master’s degree in bioinformatics or computational biology
* Experience from working in a Linux/Unix environment.
* Programming experience in Python and R.
* Hands-on experience from working with Illumina sequencing data.
* Highly motivated scientist and commitment to scientific excellence
* A 3-year contract with the possibility to prolong (payment according to TV-L (E13 / 65%))
* Access to the Leibniz-Rechenzentrum (LRZ)
* A state-of-the-art facility, with mouse phenotyping, human iPS cell, single-cell sequencing to name a few.
* A highly motivated and international institute with a high PostDoc to student ratio.
* Membership in the TUM Graduate School and benefit from educational programs etc.
The TUM aims to increase the diversity of its staff substantially. As an equal opportunity and affirmative action employer, the TUM explicitly encourages nominations of and applications from women and all others who would bring additional diversity dimensions to the university's research and teaching strategies.<br>
Please send your complete application documents (cover letter, C.V., certificates) via email to:
Technische Universität München TUM<br>
Institute of Pharmacology and Toxicology<br>
Biedersteiner Strasse 29<br>
80802 Munich, Germany<br>
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