28.04.2022, Wissenschaftliches Personal
A PhD position is available in the laboratory for Cellular Protein Biochemistry at the Technical University of Munich (TUM) Department of Chemistry and Institute for Advanced Study.
Our laboratory aims at understanding how proteins fold, assemble and are scrutinized by the cellular quality control machinery. We are particularly interested in proteins of the secretory pathway - proteins that are ultimately secreted or localized on the cell surface and allow cells to interact with their environment. We use an interdisciplinary approach from protein biochemistry to cell biology to analyze the machinery and mechanisms that monitor cellular protein biogenesis.
Membrane proteins make up one third of the human proteome. They are critical for any cellular function from movement to immune defense. Membrane proteins are major drug targets and their mutations cause numerous severe human diseases. Despite these key roles in biology and medicine, cellular mechanisms of membrane protein biogenesis remain ill-defined.
This project will investigate how molecular chaperones support and control membrane protein biogenesis. It will focus on two major aspects: First, novel endoplasmic reticulum chaperones we have identified in our lab with hitherto mostly unknown functions. Second, on the question of how molecular chaperones work together on a molecular level to support and control membrane protein biogenesis. The project thus has the potential to provide exciting insights in the molecular biology of cells. To achieve this, the project will use state-of-the-art cell biological approaches from microscopy via gene-knockouts to mass spectrometry and will build on our existing collaborations with cryo-EM labs.
You should hold a Diploma/Master’s degree (or equivalent) in Biochemistry, Cell Biology or related fields. Previous experience in mammalian cell culture and protein biochemistry is required. Experience in gene editing techniques, protein (crosslinking) mass spectrometry and/or fluorescence microscopy is a benefit.
THE ENVIRONMENT AND THE POSITION:
The Technical University of Munich (TUM) is a leading research university in Europe. We are offering excellent working conditions, participation in a structured PhD program at the TUM graduate school and an international research environment. The salary is in accordance to the Public Sector Collective Agreement on Länder (TV-L E13/65%). The position is available from August 2022 on. Only applications received until May 31st 2022 will be considered.
The application should contain a CV, (degree) certificates, a letter of motivation and at least two possible references. Please send your application as a single pdf-document by email to: email@example.com
TUM is an equal opportunity employer. Qualified women are therefore particularly encouraged to apply. Applicants with disabilities are treated with preference given comparable qualification.
further information: www.cell.ch.tum.de
Data Protection Information:
When you apply for a position with the Technical University of Munich (TUM), you are submitting personal information. With regard to personal information, please take note of the Datenschutzhinweise gemäß Art. 13 Datenschutz-Grundverordnung (DSGVO) zur Erhebung und Verarbeitung von personenbezogenen Daten im Rahmen Ihrer Bewerbung. (data protection information on collecting and processing personal data contained in your application in accordance with Art. 13 of the General Data Protection Regulation (GDPR)). By submitting your application, you confirm that you have acknowledged the above data protection information of TUM.
Phd Student, Institute of Bioorganic Chemistry Polish Academy of Sciences, Poland, 16 days ago
KEY WORDS: neurodegenerative disease, SCA3, spinocerebellar ataxia 3, ataxin-3, ATXN3, SCA3 mouse, knock-in, mutant protein, PolyQ, CAG repeats, autophagy, proteasome Principal Investigator: Macie...
Ph D Position: Bottom Up Reconstruction Of A Self Dividing Artificial Cell Using Microfluidics, Katholieke Universiteit Leuven, Belgium, about 4 hours ago
What distinguishes a living organism from a simple mixture of chemical reactions? It is generally agreed that a living organism needs to satisfy a basic set of conditions: compartmentalize its com...
Ph D Student Position In The Field Of Mammalian Neurodevelopment, Université Catholique de Louvain, Belgium, 29 days ago
The mammalian cerebral cortex plays key roles in cognition, sensory and motor functions, and the control of our emotions. The proper execution of these tasks depends on a long process of embryonic...
Ph D Candidate At Fhml Nutrim / Dept. Of Pharmacology And Toxicology For Assessing The Safety Of Lab..., Maastricht University (UM), Netherlands, 15 days ago
To get our diet within planetary boundaries, a shift towards alternative food systems is urgently needed. Cellular agriculture is a revolutionary approach to produce proteins. The current project ...
Postdoctoral Opportunity In Structural Biology Of Membrane Proteins (U Ottawa / Canada), Canadian Society for Molecular Biosciences CSMB, Canada, about 8 hours ago
My laboratory at the University of Ottawa Faculty of Medicine is recruiting one postdoctoral fellow to carry out structural biology studies of integral membrane proteins. We employ an integrative ...
Ph D Student B Cell Differentiation, Sanquin Blood Supply Foundation (Sanquin), Netherlands, about 22 hours ago
The program investigates regulation of antibody responses to be able to prevent occurrence of unwanted antibody responses against red blood cells (RBCs), platelets or other blood products. The pos...