PhD position – BIOCHEMISTRY AND BIOTECHNOLOGY

05.10.2021, Wissenschaftliches Personal

A PhD position is available in the laboratory for Cellular Protein Biochemistry at the Technical University of Munich (TUM) Department of Chemistry.

Our laboratory aims at understanding how proteins fold, assemble and are scrutinized by the cellular quality control machinery. We use an interdisciplinary approach from protein biochemistry to cell biology to analyze the machinery and mechanisms that monitor cellular protein biogenesis. One major model system in our laboratory are interleukins, key signaling molecules in our immune system. We use insights into their biogenesis to rationally engineer new immunomodulatory biomolecules.

JOB DESCRIPTION
The ideal candidate will engineer novel immunomodulatory proteins guided by biochemical, structural and in silico analyses. Biochemical approaches in combination with molecular immunology studies will be used to decipher the mechanism of action of these immune signaling molecules. Ultimately, these insights will guide the translation of basic research into development of novel first-in-class biopharmaceuticals. With these new pharmaceuticals we aim to help patients with high-unmet medical need diseases.

RESPONSIBILITIES
• Engineering of proteins with immunomodulatory functions
• Protein expression and purification
• Biochemical and biophysical protein analytics
• Molecular immunology studies
• Ex vivo and in vivo animal studies (in collaboration)
• Translation of basic research into medical application

QUALIFICATIONS
• MSc in biochemistry or similar fields
• Expertise in protein expression, protein purification and biophysical characterization
• Expertise in mammalian cell culture and molecular immunology is a plus
• Experience in protein engineering as well as (pre-)clinical development of biopharmaceuticals and molecular immunology is a plus
• Know-how in GLP and GMP requirements is a plus

THE ENVIRONMENT AND THE POSITION
The position is associated with the laboratory of Cellular Protein Biochemistry (www.cell.ch.tum.de) at the Technical University of Munich (TUM), a leading research university in Europe. The salary is in accordance to the Public Sector Collective Agreement on Länder (TV-L E13/65%). The earliest starting date is January 15th, 2022. Only applications received until November 30th 2021 will be considered.

We are looking forward to your application including a CV, (degree) certificates, a letter of motivation and at least two possible references. Please send your application as a single pdf-document by email to: [email protected] .

TUM is an equal opportunity employer. Qualified women are therefore particularly encouraged to apply. Applicants with disabilities are treated with preference given comparable qualification.

Data Protection Information:
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Kontakt: [email protected]

http://www.cell.ch.tum.de