PhD Graduate Student (f/m/d)

The Clinic for Radiation Oncology in cooperation with the Institute of Pathology at the University Medical Center Göttingen is looking for a

• Limitation: Initially limited to 36 months
• Working period: part-time 65%
• Tariff: salary according to TV-L
• Announcement published on 25.10.2021
• Vacancy from 25.10.2021
• Application deadline: 31.12.2021

The project:

In cooperation between the Clinic for Radiation Oncology and Radiotherapy (PD Dr. Rami El Shafie / Prof. Dr. Stefan Rieken) and the Institute of Pathology (Dr. Hanibal Bohnenberger / Prof. Dr. Philipp Ströbel), we aim to identify molecular predictors for the response to radiotherapy. The focus lies on lung cancer, being a field where treatment is increasingly determined by molecular stratification. In addition to cell survival assays following radiotherapy, our project will comprise multigene sequencing and the analysis of phosphoproteomic signaling signatures. In this way, we aim to characterize intracellular signaling pathways (e.g. of receptor tyrosine kinases), that limit the response to radiotherapy and that could potentially be influenced pharmacologically. Furthermore, identified biomarkers will be assessed with the help of a translational patient database to determine their clinical relevance.

Other keywords related to the topic:

• Lung cancer, radiotherapy, phospho-proteomics, mass spectrometry, multigene sequencing

Methods:

• Primary working site is the lab of the “Tissue Proteomics” working group, group lead: Dr. Hanibal Bohnenberger, Institute of Pathology
• Human cell culture, multigene sequencing, mass spectrometric phospho-proteomics, siRNA / shRNA / CRISPR, Western blots, viability assays, immunohistochemistry, histopathological analysis of human tissue samples
• Clinical / translational database analysis, biostatistics

Our latest publications on the topic:

• Yao S; […] Bohnenberger H, TLCR, 2021
• Dinter H & Bohnenberger H; […] Ströbel P, JTO, 2019
• Bohnenberger H et al, Embo Mol Med, 2018
• El Shafie RA; […] Christopoulos P et al., ESMO Open, 2021
• Bozorgmehr F; […] Rieken S et al., BMC Cancer, 2019
• Christopoulos P; […] El Shafie RA et al., Lung Cancer, 2020
• Eichkorn T; […] El Shafie RA et al., Front Oncol, 2020

We offer:

• A very exciting and cutting-edge research field
• Individual support by the Clinic for Radiation Oncology and Radiotherapy and the Institute of Pathology
• Clear, medically relevant, translational scientific problems
• The use of a broad spectrum of molecular, cell biology and mass spectrometric / phospho-proteomic techniques
• State-of-the-art laboratory equipment including two Thermo Scientific mass spectrometers of the newest generation (Eclipse and Exploris480)
• A perspective for long-term employment in further projects based at the laboratory of the Clinic for Radiation Oncology and Radiotherapy

We are looking for:

• Candidates with a very good master's degree for molecular medicine, biology, biochemistry or comparable degrees
• Candidates with high self-motivation and great interest in translational cancer research
• Experience in the management of scientific databases as well as basic skills in the fields of biostatistics / bioinformatics. Basic programming skills would be ideal.
• Experience with molecular and cell biology working methods such as siRNA / shRNA / CRISPR as well as experience in dealing with human cell cultures would be desirable
• Knowledge of the regulation of intracellular signaling pathways by post-translational modification and its mass spectrometric analysis would be ideal

The start of the work is by arrangement and is flexible.

The University Medical Center Göttingen is committed to professional equality. We therefore seek to increase the proportion of under-represented genders. Applicants with disabilities and equal qualifications will be given preferential treatment.

We look forward to receiving your application by 31.12.2021:

University Medical Center Göttingen

Clinic for Radiation Oncology and Radiotherapy

Prof. Dr. Stefan Rieken

Director

37099 Göttingen

Tel.: 0551/39-64501

Contact person: PD Dr. med. Rami El Shafie, Deputy Director of the Clinic for Radiation Oncology and Radiotherapy rami.elshafie@med.uni-goettingen.de

Please send your application only via e-mail as a PDF-file.

Travel and application fees cannot be refunded or transferred.

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