PhD Candidate (m/f/d): Bioimaging

The Leibniz-Institut für Analytische Wissenschaften - ISAS - e. V. develops efficient analytical methods for health research. Thus, it contributes to the improvement of the prevention, early diagnosis, and therapy of diseases like cardiovascular diseases, autoimmune diseases or cancer. Overall, the institute strives to advance precision medicine by combining knowledge from different fields such as biology, chemistry, pharmacology, physics, and computer science. ISAS is a member of the Leibniz Association and is publicly funded by the Federal Republic of Germany and its federal states.

At our location in Dortmund we invite applications for a

for the subproject "P2: targeting cardiac macrophages" as part of the DFG-funded Research Training Group "GRK 2989: Targeting Cellular Interfaces in Reperfused Acute Myocardial Infarction (TCI repAMI)".

The PhD project addresses the role of tissue-resident and inflammatory recruited macrophage subpopulations with regard to their repair mechanisms and their influence on tissue regeneration and fibrosis in response to repAMI. Using various imaging techniques, such as confocal laser scanning microscopy and light-sheet fluorescence microscopy, as well as flow cytometric and mass spectrometric analyses, the recruitment and polarization mechanisms in the individual inflammatory niches will be addressed.

• Planning and independent execution of experiments
• Establishment of new methods and sample preparation strategies
• Preparation of human and murine samples
• Coordination of co-operation projects
• Independent data processing and analysis
• Publishing on the research topic, preparation of contributions for reports and presentations
• Other administrative tasks

Your profile

• Master's, diploma or equivalent degree in natural sciences, preferably in biology or biochemistry
• Willingness for interdisciplinary scientific work, ability to work in a team, open-mindedness, commitment are required
• Very good knowledge of German for the exchange with project partners and the public, as well as good written and spoken English skills are essential
• Confident handling of Microsoft Office (Excel, PowerPoint, etc.) and image processing software (e.g. ImageJ, Imaris)
• Practical experience with fluorescence microscopy methods (confocal laser scanning microscopy, microscopy, light sheet fluorescence microscopy) and flow cytometry is an advantage
• Experience in the field of immunology is desirable
• Willingness to perform animal experiments; experience and FELASA B certificate are desirable

We offer

• A clear research topic as well as multifold training and support for PhD students in framework of ISAS and the Leibniz association
• Training and scientific development opportunities in an international environment and an excellent working atmosphere in a very dynamic and professional team
• Extensive state-of-the-art equipment and infrastructure in various analytical methods
• The opportunity to present your data on international conferences and participate in workshops

Non-residents who apply for this job will receive help from the institute to find accommodation and to handle authorities. Applications from disabled applicants are welcome. ISAS supports the principle of equal opportunity for all employees and would therefore particularly encourage women to apply.

The salary will be according to the German TV-L. The part-time position (65%) is offered for 4 years. The position is available immediately. The time limitation of the contract is based on the Wissenschaftszeitvertragsgesetz (WissZeitVG).

ISAS collects and processes the personal data of its applicants in accordance with European and German legal regulations. Further information on data protection and the processing of personal data can be found at www.isas.de/datenschutzhinweise-fuer-bewerberinnen-und-bewerber .

The closing date for applications is April 25, 2024. Please apply via our applicant portal . Informal requests (reference number 297_24_EN) are welcome and can be directed to the Human Resources team (bewerbungen(at)isas.de ). Further information about the institute can be found at: http://www.isas.de/en .