09.02.2021, Wissenschaftliches Personal
Synthetic Neurobiology Master’s project on generating genetically-engineered mammalian cells with magnetic properties for remote imaging and manipulation
Are you interested in synthetic biology, and do you want to contribute to developing novel techniques to non-invasively manipulate biological systems using magnetic fields?
Then you are likely interested in projects on how to genetically engineer mammalian cells in our laboratory (westmeyerlab.org) at the Munich School of Bioengineering (https://www.bioengineering.tum.de/) of TUM.
In this project, we build on our previous work to genetically engineering mammalian cells to render them magnetic. To achieve this, we use different approaches: 1.) Rational design of genetic frameworks yielding magnetic structures in mammalian cells. 2.) Reverse engineering of biological entities that are known to generate magnetic biominerals.
Summary Synthetic Biology Master’s project on generating genetically-engineered mammalian cells with magnetic properties for remote imaging and manipulation
Keywords synthetic biology, biological engineering, protein engineering, genetic circuit engineering, magnetism, bio-magnetism, magnetogenetics, CRISPR technology, molecular imaging, neurobiology, Electron Microscopy (EM), super-resolution light microscopy
Your Profile excellent grades in your Bachelor studies or an excellent and recent Bachelor’s or Master’s degree in synthetic biology, biological engineering, biochemistry, biophysics, neurobiology, biomedical engineering, or related academic programs, excellent knowledge in molecular biology, advanced cloning, and mammalian cell culture, a keen interest in bio-magnetism and genetic tools for cell manipulation, as well as neurobiology, a strong interest in de novo protein design, the ability to be self-motivated and work with an interdisciplinary team of bioengineers, biochemists, neuroscientists, and data scientists, excellent English language and organizational skills an openness and mobility to collaborate with our partners at Max Planck Institutes, MIT, Caltech, and the University of Washington.
TUM The Technical University of Munich (TUM) combines top-class facilities for cutting-edge research with unique learning opportunities for students. It is committed to finding solutions to the major challenges facing society as we move forward: Health & Nutrition • Energy & Natural Resources • Environment & Climate • Information & Communications • Mobility & Infrastructure. The university thinks and acts with an entrepreneurial spirit. Its aim: to create lasting value for society. All this combines to make it one of Europe's leading universities.
Applications from disabled persons with essentially the same qualifications will be given preference. TUM strives to raise the proportion of women in its workforce and explicitly encourages applications from qualified women.
Please send your letter of motivation and your complete CV to email@example.com. Please also note: https://portal.mytum.de/kompass/datenschutz/Bewerbung/.
References:  Sigmund, F., Pettinger, S., Kube, M., Schneider, F., Schifferer, M., Schneider, S., Efremova, M.V., Pujol-Martí, J., Aichler, M., Walch, A., Misgeld, T., Dietz, H., Westmeyer, G.G., 2019. Iron-Sequestering Nanocompartments as Multiplexed Electron Microscopy Gene Reporters. ACS Nano 13, 8114–8123. doi:10.1021/acsnano.9b03140
 Sigmund, F., Massner, C., Erdmann, P., Stelzl, A., Rolbieski, H., Desai, M., Bricault, S., Wörner, T.P., Snijder, J., Geerlof, A., Fuchs, H., Hrabe de Angelis, M., Heck, A.J.R., Jasanoff, A., Ntziachristos, V., Plitzko, J., Westmeyer, G.G., 2018. Bacterial encapsulins as orthogonal compartments for mammalian cell engineering. Nat Commun 9, 1990. doi:10.1038/s41467-018-04227-3
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