Subject and aim:
Subtypes NaV1.7, NaV1.8 and NaV1.9 of voltage-gated sodium channels (NaV channels) are important for the function of nociceptive neurons (so-called pain receptors) and thus play a central role in pain perception. In addition to NaV-associated gene mutations, which cause either congenital analgesia or chronic pain in affected patients (Nat Genet 45: 1399-1404; Nat comm 6: 10049), our group is also studying the functional modulation of the channel proteins by reactive oxygen species (ROS), the accumulation of which is associated with chronic pain of various etiologies. We aim to quantitatively understand functional alterations of NaV channels caused by endogenous and exogenous factors and their impact on human pain perception.
Methods:
In this project, molecular biology methods (PCR-based DNA mutagenesis), cultivation and transfection of mammalian cells, isolation of primary neurons, as well as electrophysiological assays (patch-clamp, multi-electrode array) will be employed. All methods are well established in the group.
Requirements:
We are seeking an enthusiastic and highly motivated candidate who holds a degree in biology, biochemistry, biophysics, molecular life sciences or a similar subject and who has a strong interest to work on interdisciplinary scientific questions. We expect solid hands-on laboratory experience, good communication skills and the ability to work in a team.
Your contact:
For questions regarding the position please contact Prof. Dr. Enrico Leipold. Please send your application including a motivation letter, your CV and two references as a single pdf file (max. 4 MB) to:
Prof. Dr. Enrico Leipold
Neurowissenschaften in der Anästhesiologie
Universität zu Lübeck
CBBM – Center of Brain, Bahaviour and Metabolism, Haus 66
Ratzeburger Allee 160
23562 Lübeck
Tel.: +49 451 3101 8610
Mail: [email protected]
Web: https://www.cbbm.uni-luebeck.de