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Hematopoietic stem cells (HSCs) ensure the lifelong production of all blood cell types. With age, HSCs undergo functional and molecular changes that impair their regenerative capacity and contribute
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cells. Proteomic approaches have identified several surface proteins that are overexpressed in glioblastoma stem cells compared with non-tumour cells, and whose role in glioblastoma biology remains to be
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the vascular organoid model, to establish a causal link between these target genes and the vascular calcification phenotype. This PhD project, at the interface of vascular biology, immunology, stem cell biology
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, neurodegeneration, advanced microscopy, stem cell biology, and cell biology. The project will leverage state-of-the-art imaging facilities and established human iPSC-derived models of Alzheimer's disease. The work is
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neural stem cell (NSC) niche. Recent studies have revealed key aspects of human rhombic lip (hRL) organization and shown that defects in its development underlie several human syndromes. These findings
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dynamics Experience in human stem cell biology and work with organoids, e.g. iPSC culture, neural differentiation, brain organoid generation is a strong asset Familiarity with data analysis and scientific