The Thierry Laboratory Biomarkers for Precision Medicine at IRCM (Cancer Research Institute of Montpellier) is looking for a Postdoctoral fellow to contribute to the team's effort in basic and clinical studies such as the MyProbe program.
Duration of recruitment: 4 months recruitment with possibility of renewal.
We are particularly interested in circulating biomarkers. A particular effort is devoted to the expression of new molecular and genetic markers, notably through the analysis of circulating DNA and RNA. Cancerous tumors release DNA (cirDNA) into the bloodstream, which is proving to be a biological source of tumor analysis and a diagnostic tool with great potential. cirDNA is a breakthrough technology in oncology diagnostics. Not only has its theranostic potential been validated, but it holds great promise for longitudinal disease management (detection of residual disease, monitoring of treatment efficacy and identification of resistance mechanisms, monitoring of recurrence and possibly for screening).
Our team is one of the most important contributors to the cirDNA study by proving the validity and clinical utility of cirDNA analysis for colorectal cancer (CRC) patients. Our research also focuses on investigating the other potentialities of cirDNA, including: (i), in the detection of mutations following targeted therapy; (ii), developing the IntplexTM test (a quantitative multi-marker analysis of cirDNA); (iii), proposing the first guidelines for pre-analytical conditions; (iv) the impact of epidemiological factors on the detection of cirDNA; (v) in the follow-up of patients with colorectal , pancreatic, breast and bronchial cancers; (vi) the prognostic power of cirDNA; and (vii) as a screening tool for a universal cancer test. In addition to working on applications of cirDNA as a diagnostic tool in oncology, our team has also been involved in long-standing basic research programs on the structure, origin and functions of cirDNA, and in particular has demonstrated that a large proportion of cirDNA originates from extracellular neutrophil traps (NETs), either in the presence of infection (such as COVID-19) or in cancer. The team has also recently discovered the presence of functional circulating cell-free mitochondria in the blood.
The team's program combines basic, technological and translational research.
Main activities:
- Perform analytical experiments in molecular biology
- Perform analytical experiments in molecular biology on clinical samples
- Perform analytical experiments in cellular biology
- Tracing and report writing
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