PhDs evolutionary genomics of sex chromosomes (M/F)

Updated: about 2 months ago
Location: Montpellier, LANGUEDOC ROUSSILLON
Job Type: FullTime
Deadline: 22 Mar 2024

2 Mar 2024
Job Information
Organisation/Company

CNRS
Department

Centre d'écologie fonctionnelle et évolutive
Research Field

Biological sciences
Environmental science
Researcher Profile

First Stage Researcher (R1)
Country

France
Application Deadline

22 Mar 2024 - 23:59 (UTC)
Type of Contract

Temporary
Job Status

Full-time
Hours Per Week

35
Offer Starting Date

1 Oct 2024
Is the job funded through the EU Research Framework Programme?

H2020 / ERC
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The students will receive comprehensive training in state-of-the-art evolutionary genomics and theoretical population genetics. The students will spend most of their time in the Genetic and Evolutionary Ecology group (GEE) at the Centre d'Ecologie Fonctionnelle et Evolutive (CEFE), a large, ecology and evolution-focused research institute in Montpellier, Southern France, with possible visits of project partners elsewhere in France. Montpellier is a lively student town with a beautiful historic center, located about 10 km from the Mediterranean Sea. These PhDs are parts of an advanced ERC project ('RegEvol', Thomas Lenormand), addressing novel ideas and theoretical predictions on the role of regulatory evolution for several important fundamental topics in evolutionary biology (sex chromosomes, maintenance of sex, complexity of gene networks, etc.). The students will join the team working on this project, including Aline Muyle, Christoph Haag, Denis Roze, Sylvain Glémin, and Thomas Lenormand (who will be involved in the PhD supervision), as well as other people recruited on the project.

Genomics analyses and theoretical approaches towards understanding sex chromosome evolution
Sex chromosomes have evolved independently in a vast number of species and share common features, including recombination suppression, degeneration, and dosage compensation. Despite a long history of theoretical investigations, it is still unclear how and why these features evolve. New models developed by our team suggest an important role of regulatory changes during early evolution of sex chromosomes and propose new ways to analyze genomic data to test different theories. In this currently fast-moving field, it is crucial to document and scrutinize the early evolution of very young sex-chromosomes.
Within this research project, we are looking for two PhD students who will carry out tests of these theories. These tests will employ integrative genomic and theoretical approaches to elucidate the mode of evolution of young sex chromosomes in three model systems : a neo-W in Daphnia magna, as well as independently evolved sex chromosome strata in several Silene and Artemia species. Each model system present interesting specific features. The Daphnia system consists in a very recent sex-like chromosome that evolves without obligate sexual dimorphism. This system is probably less than 20,000 yrs. old. The Artemia system allows to study young strata in sexual species and related asexual lineages. The Silene system offers replicated young strata with excellent genomic resources. The two PhDs are expected to work in collaboration, on several of these models, but each with their separate biological questions, the details of which will be decided in concertation with the students. Each subject will therefore address transversal questions revolving on the test of theories for sex chromosomes, rather than being focused each on a single model system. Depending on the interests of the student, the PhDs may include multilocus theory and simulations to further develop models of sex chromosome evolution.

Candidate requirements:
(1) Enthusiasm and genuine curiosity for evolutionary genetics, genomics, and evolutionary biology.
(2) An undergraduate degree in the subject area of evolutionary biology. Experience with genomics and/or population genetics and/or evolutionary theory is desirable.
(3) Strong quantitative skills. Experience with programming or bioinformatics is desirable.
(3) Strong oral and written communication skills in English (the work language for science at the CEFE is English).
(4) Ability to work both independently and in a highly collaborative environment.
(5) Well organized and highly motivated.


Requirements
Research Field
Biological sciences
Education Level
PhD or equivalent

Research Field
Environmental science
Education Level
PhD or equivalent

Languages
FRENCH
Level
Basic

Research Field
Biological sciences
Years of Research Experience
None

Research Field
Environmental science
Years of Research Experience
None

Additional Information
Website for additional job details

https://emploi.cnrs.fr/Offres/Doctorant/UMR5175-THOLEN-004/Default.aspx

Work Location(s)
Number of offers available
2
Company/Institute
Centre d'écologie fonctionnelle et évolutive
Country
France
City
MONTPELLIER
Geofield


Where to apply
Website

https://emploi.cnrs.fr/Candidat/Offre/UMR5175-THOLEN-004/Candidater.aspx

Contact
City

MONTPELLIER
Website

http://www.cefe.cnrs.fr/

STATUS: EXPIRED

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