6 Apr 2024
Job Information
- Organisation/Company
CNRS- Department
Institut Cochin- Research Field
Pharmacological sciences
Engineering
Technology- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
26 Apr 2024 - 23:59 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
35- Offer Starting Date
2 Sep 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The Cochin Institute is one of the leading French multidisciplinary biomedical research centers, jointly administered by Inserm (U1016), CNRS (UMR 8104), and the University of Paris (UMR-S1016). The Institute is located on the site of the Cochin-Port-Royal Hospital (AP-HP Center), within 5 buildings (Méchain, Gustave Roussy, Faculté Cochin, Hardy, and Cassini).
The Cochin Institute is organized into 5 scientific axes, each consisting of 10 to 12 teams, and one technological axis:
- Cancer
- Immunology
- Microbiology
- Metabolism and endocrinology
- Cellular plasticity and reproduction
- Technological platforms: Since its inception, the Cochin Institute has heavily invested in the development of high-performance and innovative technological platforms, serving its teams as well as all teams of the University and external public or private teams.
We have recently developed highly sensitive biosensors to monitor tau conformational change and aggregation, which are key processes in the progression of several neurodegenerative diseases known as tauopathies. The project aims to further optimize and explore these biosensors to investigate the underlying molecular mechanisms governing tau aggregation, as well as to investigate in vivo application of the sensor to monitor tau pathology in well-characterized transgenic mice. The PhD student will use techniques of molecular biology to design and develop new biosensors, and cellular biology to express the sensors in a cellular context (neuronal and non-neuronal) and develop stable biosensor cell lines. Biosensor cells will be challenged with different stimuli to identify conditions that favor or impair the pathological conformational change or aggregation of tau. Biosensors will also be used to validate drug candidates suspected to interfere with tau aggregation/seeding processes as a proof-of-concept of their applicability in screening assays. The student will also participate in the in vivo experiments of monitoring of tau aggregation by bioluminescence.
The main techniques to be performed by the student comprise: cell culture and cell signaling, molecular cloning, nanoluciferase complementation assay, western blot, confocal microscopy, in vivo bioluminescence, immune-histology/cytology.
Requirements
- Research Field
- Pharmacological sciences
- Education Level
- Master Degree or equivalent
- Research Field
- Engineering
- Education Level
- Master Degree or equivalent
- Research Field
- Technology
- Education Level
- Master Degree or equivalent
- Languages
- FRENCH
- Level
- Basic
- Research Field
- Pharmacological sciences
- Years of Research Experience
- 1 - 4
- Research Field
- Engineering
- Years of Research Experience
- 1 - 4
- Research Field
- Technology
- Years of Research Experience
- 1 - 4
Additional Information
- Website for additional job details
https://emploi.cnrs.fr/Offres/Doctorant/UMR8104-ERICEC-002/Default.aspx
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Institut Cochin
- Country
- France
- City
- PARIS 14
- Geofield
Where to apply
- Website
https://emploi.cnrs.fr/Candidat/Offre/UMR8104-ERICEC-002/Candidater.aspx
Contact
- City
PARIS 14- Website
http://www.institutcochin.fr
STATUS: EXPIRED
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