The thesis will take place within the Epigenetic Biological Chemistry unit which brings together chemists and biologists dedicated to develop strategies to modulate epigenetic regulation. The Unit led by Dr. Paola Arimondo (DR1 CNRS) was created in January 2018. It is composed of 11 members : 4 permanent members (1 CNRS DR, 1 CNRS IR, 1 Institut Pasteur technician, 1 Institut Pasteur administrative assistant), 2 Post-docs, 2 Ph.D. students and 3 master students. The Unit works at the interface of chemistry and biology.
The aim of the thesis is to develop new molecules targeting the methylation of DNA and histones able to act on pathogens and their infection. The project is based on collaboration with Biology units of the Institut Pasteur working in the field of infectious diseases.
The unit is part of the CNRS-Institut Pasteur Joint Unit (UMR 3523) and is located in the Institut Pasteur in Paris. The Campus brings together numerous research units dedicated to AMR and epigenetics, which favors interactions and interdisciplinary projects.
Development of new chemical actives targeting epigenetic regulation to reprogram host-pathogen interactions in infectious diseases
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