PhD proposal at Université Paris Cité : Probing bioenergetics at single mitochondria by AFM-SECM microscopy
19 Mar 2024
Job Information
- Organisation/Company
Université Paris Cité- Research Field
Chemistry » Biochemistry- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
13 Jul 2024 - 23:30 (Europe/Paris)- Type of Contract
Temporary- Job Status
Full-time- Offer Starting Date
1 Oct 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The goal of this doctoral project is to study bioenergetics activities at the scale of single organelles, the mitochondria, by using an ultra-sensitive electrochemical nano-imaging technique.
Mitochondria are the "energy powerhouses” of living cells, synthesizing the chemical bioenergy fuel, ATP, under coupling with the activity of the enzymatic respiratory chain. Studying the efficiency of electron transport within the chain, via the oxidation of various coenzymes (NADH, quinone, cytochrome-c) with O2 as the final acceptor, provides information about the bioenergetics functioning of mitochondria in physio and pathological conditions. In this project, individual mitochondria will be functionally imaged, under different respiratory, redox and metabolic states, using the ultra-resolved and dual atomic force-electrochemical nanoscopy (AFMSECM). This imaging technique is currently the only one capable of constructing a topographical image of a single living mitochondrion while simultaneously mapping its redox reactivity, at an unprecedented sub-particle scale.
Keywords. Nano-bioelectrochemistry, AFM-SECM imaging, mitochondria, respiratory chain
Requirements
- Research Field
- Biological sciences
- Education Level
- Master Degree or equivalent
- Languages
- ENGLISH
- Level
- Good
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Laboratory of Molecular Electrochemistry - Universite Paris Cité
- Country
- France
- City
- Paris
- Postal Code
- 75013
- Street
- 15, rue Jean-Antoine de Baif
- Geofield
Where to apply
[email protected]
Contact
- City
PARIS- Website
https://u-paris.fr/- Street
85 boulevard Saint-Germain- Postal Code
75006
STATUS: EXPIRED
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