19 Feb 2024
Job Information
- Organisation/Company
Inserm DR Occitanie Mediterranee- Research Field
Chemistry » Analytical chemistry- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
20 May 2024 - 12:00 (Europe/Paris)- Type of Contract
Temporary- Job Status
Full-time- Is the job funded through the EU Research Framework Programme?
HE / MSCA- Marie Curie Grant Agreement Number
101119562- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Inserm offers a PhD position in the framework of the MSCA Doctoral Network MobiliTraIN (Ion Mobility Mass Spectrometry Training Network). The project aims to bring a new fundamental understanding of ion mobility-high resolution mass spectrometry (IM-HRMS), provide reference materials and guidelines for standardisation, develop state-of-the-art methods for the application of IM-HRMS in biopharmaceutical development, biological omics studies and non-target screening of contaminants, and lay the foundations for the adoption of IM-HRMS in industry by training 13 doctoral candidates.
PhD project description: The PhD project offered aims to 1) Transpose workflows for bottom-up epitranscriptomics (analysis of RNA modifications) on an ion mobility-Q-TOF plat-form, inspired by workflows for bottom-up proteomics; 2) Establish what are the advantages of ion mobility separation (a) in terms of filtering and throughput and (b) in terms of structural insight on the modifications themselves or systematic effects of modifications on oligonucleotide structures. 3) Apply this knowledge in cancer biology: get novel insight into the effect of tRNA modifications in cancer, in particular cancer adaptation (metastasis and therapy).
Secondments: This project is carried out in strong collaboration with the following groups, and visits to their laboratories are expected during the project. A willingness to travel and spend time abroad is therefore essential.
1) Host: Bruker; Supervisor: Oliver Raether; Timing: M18-M20; Length: 3 months; Purpose: Get hands-on training in the latest developments in PASEF for proteomics.
2) Host: UNIGE; Supervisor: Valérie Gabelica; Timing: M30-M32; Length: 3 months; Purpose: For selected modified tRNA involved in cancer, test the influence of modifications on the full-length tRNA or on biologically-relevant fragments, longer than those typically obtained by bottom-up workflows.
Requirements
- Research Field
- Chemistry » Analytical chemistry
- Education Level
- Master Degree or equivalent
Skills/Qualifications
- A master's degree (or equivalent) in a relevant field such as Chemistry, Biochemistry, Biophysics, or a related discipline.
- Strong background in analytical chemistry and expertise in analytical techniques - mass spectrometry in particular- would be a plus
- Skills in data analysis, including interpretation of mass spectrometry data and statistical analysis.
- Ability to work in an interdisciplinary research environment, bridging the fields of chemistry, biology, and informatics.
- Excellent written and verbal communication skills, with the ability to present research findings effectively.
- Ability to collaborate with research groups both within Inserm and during secondments to external institutions.
- Willingness to adapt to new methodologies and techniques, especially during secondments to industry partners.
- Intrinsic motivation to contribute to the objectives of the MobiliTraIN project and the ability to take initiative in research activities.
Specific Requirements
- Proficiency in operating and troubleshooting mass spectrometry instruments.
- Understanding RNA biology, particularly chemical modifications of RNA
- Proficient in laboratory techniques relevant to biochemistry and molecular biology.
- Familiarity with relevant programming languages (e.g., Python, R) and bioinformatics tools for data analysis would be a plus
- Enthusiasm for contributing to the overall goals of the MobiliTraIN project, including the development of workflows for epitranscriptomics, standardization efforts, and applications in cancer biology.
- Compliance with any regulatory or ethical requirements associated with the research, particularly when working with biological samples or human data.
Candidates must also fulfil the MSCA Doctoral Networks Eligibility Criteria stated below.
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Chemistry » Analytical chemistry
Additional Information
Benefits
Recruited researchers will be part of the MobililTraIN doctoral programme. MobiliTraIN offers:
- A thorough scientific education in the frame of a doctoral training programme.
- The possibility to participate in specific international training courses, workshops and conferences.
- A strong involvement in a European research project with high international visibility.
- The possibility to perform research visits to internationally renowned research labs in Europe.
- A prestigious three-year MSCA Fellowship.
The gross salary per year will be in the range of 2100 € N. The exact net salary is dependent on local tax and social and health insurance regulations and will be confirmed upon appointment.
Eligibility criteria
Specific Eligibility Criteria of the Horizon Europe Marie Sklodowska-Curie programme apply, including the mobility rule and the PhD rule:
- Mobility rule: Researchers must not have resided or carried out their main activity (e.g., work, study) in the country of the host organisation for more than 12 months in the 3 years immediately before the recruitment date (i.e., start of employment).
- PhD rule: Applicants must be doctoral candidates, i.e., must not already be in possession of a doctoral degree at the date of recruitment.
Applicants of all nationalities are welcome to apply.
Selection process
We will will adopt the principles of the European Charter for Researchers and Code of Conduct for the Recruitment of Researchers, promoting open, merit-based and transparent recruitment and attractive working and employment conditions.
Steps of the employement process: (1) Resume Screening; (2) Initial Screening/Phone Interview; (3) Interviewing with the team
A reserve list of candidates may be kept for up to 6 Months
Ineligible or incomplete applications will not be considered
- Website for additional job details
https://mobilitrain.eu/
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Institut de Recherche en Cancérologie de Montpellier
- Country
- France
- City
- Montpellier
- Postal Code
- 34298
- Street
- 208 avenue des Apothicaires
- Geofield
- Number of offers available
- 1
- Company/Institute
- Clinical Proteomics Platform / Institute for Regenerative Medicine & Biotherapy
- Country
- France
- City
- Montpellier
- Postal Code
- 34295
- Street
- 80 rue Augustin Fliche
- Geofield
Where to apply
[email protected]
Contact
- State/Province
Occitanie Mediterranee- City
MONTPELLIER- Website
http://www.occitanie-mediterranee.inserm.fr/- Street
60, rue de Navacelles- Postal Code
34000
STATUS: EXPIRED
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