PhD (M/F) INTERACTION OF ULTRASOUND WITH THE 3D MICROENVIRONMENT OF BONE CELLS: EXPERIMENTAL AND NUMERICAL STUDIES

5 Mar 2024
Job Information

Organisation/Company

CNRS

Department

Institut de Recherche sur les Phénomènes Hors Equilibre

Research Field

Engineering » Materials engineering
Physics » Acoustics

Researcher Profile

First Stage Researcher (R1)

Country

France

Application Deadline

25 Mar 2024 - 23:59 (UTC)

Type of Contract

Temporary

Job Status

Full-time

Hours Per Week

35

Offer Starting Date

1 Apr 2024

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Lab: The thesis will be carried out within the Biomechanics team of the IRPHé (UMR CNRS/Aix-Marseille Université/ Centrale Méditerranée) located in Marseille (France). Funding: ANR INVICT-US project. Thesis supervisors: Cécile Baron, CR CNRS (HDR), and Carine Guivier-Curien, MCF AMU (HDR) Contact: [email protected] ; [email protected]

Bone tissue is a complex biological tissue, capable of adapting to its mechanical environment by optimising its structure, a process known as bone remodelling. Ultrasound stimulation of bone regeneration (UStim) was discovered in the 1950s and has been widely studied ever since. However, the underlying mechanotransduction mechanisms (translation of mechanical stimuli into a biological response) remain poorly identified and this lack of knowledge is fuelling controversy, preventing the development of effective and optimised therapeutic tools. Characterising and quantifying the mechanical stresses induced by ultrasound stimulation on bone cells (osteocytes) is essential to understanding these mechanisms. As part of the ANR INVICT-US project, an experimental device for stimulating bone remodelling in vitro incorporating a biomimetic 3D culture medium is being developed. The aim of the thesis will be to design a multiscale, multiphysics 'digital twin' in order to identify and quantify the hydrodynamic phenomena (acoustic streaming) within this three-dimensional microenvironment that are likely to be involved in the mechanotransduction of bone cells induced by ultrasound waves.

Requirements

Research Field

Engineering

Education Level

PhD or equivalent

Research Field

Physics

Education Level

PhD or equivalent

Languages

FRENCH

Level

Basic

Research Field

Engineering » Materials engineering

Years of Research Experience

None

Research Field

Physics » Acoustics

Years of Research Experience

None

Additional Information

Website for additional job details

https://emploi.cnrs.fr/Offres/Doctorant/UMR7342-CECBAR-003/Default.aspx

Work Location(s)

Number of offers available

1

Company/Institute

Institut de Recherche sur les Phénomènes Hors Equilibre

Country

France

City

MARSEILLE 13

Geofield

Where to apply

Website

https://emploi.cnrs.fr/Candidat/Offre/UMR7342-CECBAR-003/Candidater.aspx

Contact

City

MARSEILLE 13

Website

http://www.irphe.fr

STATUS: EXPIRED