PhD in physics of active matter (M/W): Light powered vs. fuel activated micro-swimmers

Updated: 3 months ago
Job Type: FullTime
Deadline: 22 Dec 2023

2 Dec 2023
Job Information
Organisation/Company

CNRS
Department

Centre de Recherche Paul Pascal
Research Field

Chemistry » Physical chemistry
Physics » Chemical physics
Physics » Biophysics
Researcher Profile

First Stage Researcher (R1)
Country

France
Application Deadline

22 Dec 2023 - 23:59 (UTC)
Type of Contract

Temporary
Job Status

Full-time
Hours Per Week

35
Offer Starting Date

2 Sep 2024
Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Key-words: Active Brownian matter – Self-propelled particles– Light powered microswimmers – Filamentous viruses – Soft Matter

Your Profile: This PhD project is mainly experimental with multiple collaborations providing varied support and expertise. It is fundamentally interdisciplinary, combining soft matter physics, physico-chemistry, as well as the production and manipulation of biological objects. The candidates should be in possession of, or expect to attain, a Master's in a relevant discipline (Physical Chemistry, Materials science, Physics, Nanoscience, etc). Good skills in written and oral communication in English are important.

Mimicking the properties of life in artificial cells is a current research frontier between biophysics and synthetic biology. Among these properties, reproducing motility and directional swimming is major for understanding the individual and collective behavior of their more complex natural counterparts, while having strong potential for developing advanced therapies. One of the most efficient mechanisms of Brownian particle self-propulsion is based on self-phoretic swimmers that propel themselves by generating a local gradient of concentration, temperature, etc through asymmetric surface properties (Janus particles). These gradients induce surface flows that lead to directed motion. In this PhD project, we aim at designing and developing a new generation of self-propelled particles, either chemically powered by enzymatic decomposition of glucose fuel or light driven by self-thermophoresis, and asymmetrically functionalized with filamentous bacteriophages in order to improve their directional swimming efficiency. The spatiotemporal organization of these fuel and light powered nanoparticles will be studied at the single particle level thanks to advanced optical microscopy techniques in order to characterize their dynamical behavior and to understand individual and collective effects in simple and complex fluids. While addressing relevant fundamental questions, the objective of the project is to establish a proof of concept for the design of self-propelled artificial protocells capable of demonstrating efficient motility, allowing in the long term to solve some drug delivery challenges.


Requirements
Research Field
Chemistry
Education Level
PhD or equivalent

Research Field
Physics
Education Level
PhD or equivalent

Research Field
Physics
Education Level
PhD or equivalent

Languages
FRENCH
Level
Basic

Research Field
Chemistry » Physical chemistry
Years of Research Experience
None

Research Field
Physics » Chemical physics
Years of Research Experience
None

Research Field
Physics » Biophysics
Years of Research Experience
None

Additional Information
Additional comments

Funding: PopART ANR grant.


Website for additional job details

https://emploi.cnrs.fr/Offres/Doctorant/UMR5031-ERIGRE-005/Default.aspx

Work Location(s)
Number of offers available
1
Company/Institute
Centre de Recherche Paul Pascal
Country
France

Where to apply
Website

https://emploi.cnrs.fr/Candidat/Offre/UMR5031-ERIGRE-005/Candidater.aspx

Contact
Website

http://www.crpp-bordeaux.cnrs.fr/

STATUS: EXPIRED

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