16 Mar 2024
Job Information
- Organisation/Company
CNRS- Department
Laboratoire de Synthèse Organique- Research Field
Chemistry
Environmental science- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
5 Apr 2024 - 23:59 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
35- Offer Starting Date
1 Oct 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The doctoral student will work at the Laboratory of Organic Synthesis (UMR7652 - https://lso.polytechnique.fr/ ) located at the Ecole Polytechnique. He/she will be integrated into the team "New Cycloaddition Reactions", which focuses on methodological developments in synthesis.
Nitrogen‑containing heterocycles display better interactions with biological targets and therefore are prone to be effective pharmacological agents [1]. In our research group, we focus on the development of original transformations relying on cycloaddition strategies towards the rapid construction of azacycles. [2]
In this context, this project aims to investigate the reactivity of readily available precursors of 1,4 nitrogenated zwitterionic dipoles via a palladium-catalyzed decarboxylative process. These transient species will be engaged in (4+2) cycloadditions to furnish six-membered heterocycles. This underexploited strategy will allow to control the regio- and diastereoselective outcome of the transformation through a screening of the palladium ligands. Chiral ligands will also be examined to access enantioenriched structures.
1) Njardarson et al. J. Chem. Ed. 2010, 87, 1348
2) Anaïs Scuiller, Nicolas Casaretto, and Alexis Archambeau, J. Org. Chem. 2023, 88, 9941−9945.
Antoine Roblin, Nicolas Casaretto, and Alexis Archambeau, Org. Lett. 2023, 25, 6453−6458
Requirements
- Research Field
- Chemistry
- Education Level
- Master Degree or equivalent
- Research Field
- Environmental science
- Education Level
- Master Degree or equivalent
- Languages
- FRENCH
- Level
- Basic
- Research Field
- Chemistry
- Years of Research Experience
- None
- Research Field
- Environmental science
- Years of Research Experience
- None
Additional Information
- Website for additional job details
https://emploi.cnrs.fr/Offres/Doctorant/UMR7652-ALEARC-003/Default.aspx
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Laboratoire de Synthèse Organique
- Country
- France
- City
- PALAISEAU
- Geofield
Where to apply
- Website
https://emploi.cnrs.fr/Candidat/Offre/UMR7652-ALEARC-003/Candidater.aspx
Contact
- City
PALAISEAU- Website
http://lso.polytechnique.fr/
STATUS: EXPIRED
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