PhD in life science "Role of chromosome structure and dynamics in regulating meiotic recombination (M/F)
17 Jun 2026
Job Information
- Organisation/Company
CNRS- Department
Laboratoire de Biologie et Modélisation de la Cellule- Research Field
Mathematics
History » History of science- Researcher Profile
First Stage Researcher (R1)- Application Deadline
7 Jul 2026 - 23:59 (UTC)- Country
France- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
35- Offer Starting Date
1 Oct 2026- Is the job funded through the EU Research Framework Programme?
Horizon Europe - ERC- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Meiosis is a specialized form of cell division required for sexual reproduction that orchestrates the reduction in ploidy. Homologous recombination (HR) performs the informational and mechanical tasks underlying homologous recognition, synapsis, and their physical attachment to ensure proper segregation during meiosis I. Meiotic recombination is regulated to facilitate this recognition between homologs, but the molecular nature of these regulatory mechanisms remains poorly understood. The “Genome Mechanics” (GeM) research team aims to elucidate the nature of these regulatory mechanisms.
The candidate will join the GeM team, which specializes in the study of DNA breakage repair, mechanisms of genomic stability maintenance, and the 3D organization of chromosomes.
The group is part of the Laboratory of Cell Biology and Modeling, which aims to characterize the molecular bases underlying the organization and functioning of cellular processes under normal and pathological conditions. It is based at the École normale supérieure de Lyon, a leading French research and teaching institute.
This project has received ERC Consolidator funding from 2025 to 2030
Background: Meiosis is a specialized cell division required for sexual reproduction that orchestrates ploidy reduction. Homologous recombination (HR) performs the informational and mechanical tasks underlying homolog recognition, synapsis, and their physical attachment for proper segregation at meiosis I. Meiotic recombination is uniquely regulated to achieve 3 hallmark features of meiosis: the biased usage of the homologous chromosome as a repair template (homolog bias), the formation of at least one crossover (CO) per homolog pair (CO assurance), and the avoidance of two nearby COs (CO interference). The molecular nature of these regulations remains elusive.
We propose to address the role of chromosome mechanical properties in regulating meiotic recombination
Methodology: The host laboratory has developed (i) cutting edge molecular and genomics assays to chart the core recombination steps and (ii) and ambitious experimental system involving a 150 kb-long synthetic region (SynHR on Chr. IV) to simultaneously track chromosome structure and recombination in budding yeast cells. I will exploit this system to temper with the motion of these or other chromosome and determine the impact on homologs pairing and recombination in cis and trans at the level of hotspots contained in this region, or at an independent recombination hotspot on chr. III. Changes in mobility will be determined by live microscopy and forces inferred thanks to a molecular dynamics coarse-grained polymer model of meiotic chromosomes developed in the laboratory.
Where to apply
- Website
- https://emploi.cnrs.fr/Offres/Doctorant/UMR5239-CHRCHA-008/Default.aspx
Requirements
- Research Field
- Mathematics
- Education Level
- PhD or equivalent
- Research Field
- History
- Education Level
- PhD or equivalent
- Languages
- FRENCH
- Level
- Basic
- Research Field
- Mathematics
- Years of Research Experience
- None
- Research Field
- History » History of science
- Years of Research Experience
- None
Additional Information
- Website for additional job details
https://emploi.cnrs.fr/Offres/Doctorant/UMR5239-CHRCHA-008/Default.aspx
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Laboratoire de Biologie et Modélisation de la Cellule
- Country
- France
- City
- LYON 07
Contact
- City
LYON 07- Website
http://www.ens-lyon.fr/LBMC/
STATUS: EXPIRED
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