Updated: 8 months ago
Location: Tremblay en France, LE DE FRANCE
Deadline: 14 Oct 2019

Centre National de la Recherche Scientifique (CNRS) is the largest organisation of scientific research in France and home to the largest number of scientists in Europe (>25,000 researchers, engineers, technicians and administrative staff in over a thousand research units). The CNRS is a major stakeholder in and contributor to the development of European research, thus playing an important role in the advancement of scientific knowledge at both the European and global levels
ICM Foundation: L'Institut du Cerveau et de la Moelle Epinière (Brain and Spine Institute, ICM) is a private non-profit foundation that provides the technical support through shared cutting-edge core facilities small animal MRI (CENIR–SA MRI: SMALL ANIMAL MRI CORE FACILITY, histology (HISTOMICS: HISTOLOGY CORE FACILITY; as well as cellular imaging (PICPS;). Furthermore, a state- of-the-art primate experimentation facility (PHENO-PRIMR;) is operated by an experienced facility manager and qualified zootechnicians (i.e. Morgan Monfort - not financed by this grant) who perform in-vivo experiments in the best possible conditions that comply with international best standard practices.

Brain disconnection should not be considered an irremediable condition and there is a crucial need for innovative approaches to reconnect the brain. While the exploration of the relationship between brain disconnection and dysfunction is an essential scientific and clinical study that is heavily dependent on magnetic resonance imaging (MRI), the critical mechanisms involved in disconnection and recovery are not visible with MRI. In addition, the exploration of new strategies for treatment is not available for humans. Therefore, with the support of the ERC, this project proposes to extend current work from the BCBlab, research and expertise to animal studies. An animal model of disconnection will allow for the controlling of white matter disconnections and pharmacological stimulation. The overall purpose of this project is to measure the biological mechanisms that support functional recovery after a brain disconnection in the non-human primate, and subsequently manipulate this mechanism pharmacologically.

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