Tallinn University of Technology, Department of Chemistry and Biotechnology offers a 4- year PhD Position in microbiology, microfluidics and bioinformatics.
Proposed PhD topic: Antimicrobial resistance: Analysis by novel microfluidic and genomic approaches
Supervisors: Professor Ott Scheler and Professor Olli-Pekka Smolander
This PhD Project is a collaboration between Microfluidics and Bioinformatics research groups.
The aim of the project is to investigate antimicrobial resistance mechanisms with different novel high-throughput methods.
Antimicrobial resistance is a major global threat. Each year antibiotic resistant bacteria infect hundreds of thousands of people and many of these cases end fatally. There is an urgent need to understand better, how such drug resistance emerges and evolves. This would help designing better treatment strategies and combat the spread of resistance.
In this project the PhD student investigates the resistance profile of laboratory test bacteria at single cell level using droplet microfluidic methods developed recently by supervisor. Bacteria are treated with different antibiotics to see how they evolve resistance. The changes in the transcriptome and genome level are analyzed using modern next-generation sequencing tools and analysis platforms under supervision of co-supervisor.
During the project the student is predicted to spend shorter and longer visits in collaborating microfluidics labs in Poland and Sweden, and in Bioinformatics groups in Finland.
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