PhD Position in Chemistry and biotechnology, Early stage researcher

Tallinn University of Technology, School of Science, Department of Chemistry and biotechnology offers a 4-year PhD position in the field of chemistry and biotechnology.

Proposed doctoral thesis topic: "Use of heterobifunctional constructs in chemical biology and materials".

Supervisor: Senior Researcher Pavel Starkov

Abstract

Networks and their architectures are central to the mathematical and computer sciences as well as to systems biology and systems medicine. This proposal aims to transcend the concepts of network science onto synthetic chemistry and materials science. From the outset, we have identified that the concept of networks in chemistry should be divided into two separate, however, strongly intertwined research streams. We will design cell- permeable heteromultifunctional constructs to probe intracellular networks using small molecules that typically go beyond Lipinski’s rule. We will also build molecular networks (materials) by using single-precursor/fused hybrid linker-based approach and will apply them as electrocatalysts and in heterogenous catalysis for large-scale applications.

Description

Networks and their architectures are central to the mathematical and computer sciences as well as to systems biology and systems medicine. This proposal aims to transcend the concepts of network science onto synthetic chemistry and materials science. From the outset, we have identified that the concept of networks in chemistry should be divided into two separate, however, strongly intertwined research streams.

Responsibilities and (foreseen) tasks

We will design cell- permeable heteromultifunctional constructs to probe intracellular networks using small molecules that typically go beyond Lipinski’s rule. We will also build molecular networks (materials) by using single-precursor/fused hybrid linker-based approach and will apply them as electrocatalysts and in heterogenous catalysis for large-scale applications.