Postdoctoral Position within medicinal chemistry targeting disease ribosomes

Updated: 19 days ago
Deadline: 21 Nov 2019

Faculty of Health and Medical Sciences
University of Copenhagen

The Department of Drug Design and Pharmacology is offering a temporary postdoctoral position within in medicinal chemistry targeting disease ribosomes starting on 1 January 2020 or as soon as possible thereafter. The position is for 1 year.

The department
The Department of Drug Design and Pharmacology delivers research and teaching within a wide range of drug-related disciplines, spanning the molecular, cellular, and pharmacological levels. The department has approximately 300 employees.

Project description
It is becoming clear that the ribosome is not a constitutive protein production machine. Rather, its activities are likely regulated by alterations in rRNA modification states and ribosomal protein composition. Furthermore, there is accumulating evidence that pools of specialized ribosomes exist in the cell. This project hypothesizes that, during disease, ribosome pools favoring the translation of mRNAs important for the disease phenotype may become over-represented. In the present project the successful applicant will develop ligands that target disease ribosomes utilizing library screening methods in combination with structure-based drug design and organic synthesis.

The research team
The successful candidate will be employed and supervised by Professor Fredrik Björkling that run medicinal chemistry research programs at the Department of Drug design and Pharmacology, University of Copenhagen.
The candidate will work in close collaboration with two collaborating research groups:

Professor Anders Lund (cancer biology) at the Biotech Research and Innovation Centre (BRIC), University of Copenhagen and Professor Henrik Nielsen (RNA enzymes) at the Department of Cellular and Molecular Medicine, University of Copenhagen.

Your qualifications
We expect you to be a highly motivated and highly ambitious scientist with the following qualifications:

  • Hold a PhD degree (or equivalent)
  • Documented experience in medicinal chemistry, incl. library design and structure-based drug design using computational chemistry techniques
  • Expertice in organic synthesis
  • Excellent technical and collaborative skills
  • Excellent English skills written and spoken

Terms of salary and employment
The employment as postdoc is a full time and fixed-term position for 1 year. Starting date is 1 January 2020 or after agreement.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Currently, the monthly salary starts at 34,360 DKK/ approx. 4,590 Euro (Oktober 2019-level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

Information
For further information, please contact Professor Fredrik Björkling, fb@sund.ku.dk .  

You can also find more information at www.drug.ku.dk

Application
The application, in English, must be submitted electronically by clicking “APPLY ONLINE” below.

Please include:

  • Application/Cover letter including motivation
  • Curriculum vitae
  • Diplomas (PhD and MSc)
  • A complete list of publications indicating articles relevant to the position, including copies of these articles (max. 5)
  • Documentation of teaching qualifications 1
  • Recommendation letters if relevant

The deadline for applications is 21 November 2019

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/ .

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

Interviews are expected to be held in week 49.

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.


Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.


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