Postdoc position in Single-nuclei and cell-free DNA studies of fatty liver disease in humans

Updated: about 1 month ago
Deadline: 22 Dec 2019

Novo Nordisk Foundation Center for Basic Metabolic Research

Faculty of Health and Medical Sciences

University of Copenhagen

We are looking for a highly skilled researcher with experience from single-nuclei RNA sequencing and single-nuclei chromatin accessibility sequencing of human liver samples, for a 2-year postdoc position commencing on February 1, 2020. The position involves both generation of data and bioinformatic analyses.

Background
The Novo Nordisk Foundation Center for Basic Metabolic Research’s vision is to strengthen interdisciplinary research that transforms our basic understanding of the mechanisms that underlie metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. We were established in 2010 and in 2017 we moved into new laboratories, offices and meeting rooms in the Maersk Tower. 

The Novo Nordisk Foundation has financed the Center through two generous grants. The latest, in 2018, has allowed the Center to develop and expand its five enabling biology and technology platforms. The Center has around 200 employees from all over the world who work in a highly collaborative research environment across a range of biomedical disciplines. You can read more about us here: http://cbmr.ku.dk . 

The position is in the Human Genomics and Metagenomics in Metabolism program in the group led by Professor Torben Hansen. The Hansen Group’s major research interests are genetic discovery and epidemiology , and the impact of the gut microbiome on obesity, type 2 diabetes and metabolic health. Professor Hansen is heading the MicrobLiver initiative addressing the interaction between the gut microbiome and early liver fibrosis. You can read more here: https://cbmr.ku.dk/research/human-genomics-and-metagenomics-in-metabolism/hansen-group/

Project description
The candidate will work on a collaborative project together with Associate Professor Tune H. Pers, who heads the Center’s single cell omics platform. The primary focus will be on mapping transcriptional changes in the liver of humans with various degrees of fatty liver disease and cirrhosis. To this end, the candidate will employ single-nuclei RNA sequencing together with single-nuclei ATAC-seq. Part of the project will include setting up and optimizing these technologies. The candidate will also use the discovered liver cell specific transcription factors and chromosome structure to identify targets for a scalable “liquid biopsy”.

We are seeking experienced candidates with a background in molecular biology, human physiology and metabolism. The successful candidate will benefit from a dynamic, internationally diverse and stimulating scientific environment in a well-equipped laboratory to elucidate the molecular mechanisms controlling metabolic functions.

Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and qualifications:

  • PhD in biochemistry, molecular biology, cell biology, physiology or related science.
  • Knowledge in human physiology and metabolic diseases.
  • Previous experience with animal work (FELASA certification).
  • Expertise in molecular and cellular biology, including histology , gene transfer or silencing, gene expression analysis, microscopy and flow cytometry.
  • Practical experience in single-cell technologies including ATAC-seq, preferably familiarity on the Chromium Controller (10X Genomics), which will be used for the project.
  • Experience performing QC and analyzing singe-cell data.
  • Excellent scientific track record in cell signaling, cell biology or regulation of metabolism, evidenced by at least 1 first author publication in a peer-reviewed journal.
  • Excellent written and oral communication skills, preferably experience in project coordination.

 Terms of employment
The postdoc position is a full-time position for 2 years. Starting date is February 1, 2020.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations). Depending on qualifications, a supplement may be negotiated.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The positions are covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

Questions
For further information about the position, please contact Professor Torben Hansen at torben.hansen@sund.ku.dk . For questions regarding the recruitment procedure, please contact SUND HR CBMR at SUND-HR-CBMR@sund.ku.dk .

Application procedure
Your online application must be submitted by clicking ‘Apply now’ below. Furthermore, your application must include the following documents in PDF format: 

1. Motivated letter of application (max. one page)

2. Curriculum vitae (your ORCID must be included)

3. Full list of publications

4. References (name and contact details of at least two references)

Application deadline: December 22, 2019, 23.59pm CET

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements. 

The further process
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed, each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

The applicants will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

 The University of Copenhagen wishes to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.


Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.


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