Postdoc position in advanced imaging of genome integrity pathways at The Novo Nordisk Foundation...

Updated: 3 months ago
Job Type: FullTime
Deadline: 16 May 2020

A postdoc position is available in Jiri Lukas Group (Chromosome Stability and Dynamics) at the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen.

*Research area*
The main interest of the Lukas lab is how DNA repair and signaling proteins wire themselves into functional pathways, how these pathways are organized in the three-dimensional space of the cell nucleus, and how malfunctions of these mechanisms impact on etiology of cancer and other diseases marked by unstable genomes.

Most recently, the Lukas lab became focused on DNA replication stress and its role in fueling genome instability during oncogenic transformation, heritability of chromosomal lesions generated by DNA under-replication or defects in chromosome segregation, and rate-limiting protein guardians of DNA repair fidelity as potentially drug gable targets of cancer treatment. To generate a competitive niche in these focus areas, the Lukas laboratory has been very active in pioneering advanced light microscopy techniques combined with genome editing, genetic silencing and computation-based phenotypic readouts, with the aim to visualize fundamental principles of genome maintenance in its physiological environment.

The position is available in summer 2020. The starting date is flexible and will be agreed with the selected candidate.

Candidates for the postdoctoral positions must hold a PhD degree (or equivalent). The successful candidate is expected to have tractable achievements in genome integrity research (original discoveries published as a first author in peer-reviewed international journals) and demonstrate broad range of skills in advanced light microscopy. Specifically, we are looking for experience within the following areas:

Conceptual insight in DNA replication, DNA damage signaling and cell cycle regulation.
Experience with wide range of light microscopy techniques and advanced image analysis.
Hands-on proficiency in establishing cellular models with fluorescently-labelled proteins.

The new postdoc is expected to work in the area of spatio-temporal regulation of genome maintenance with an emphasis on stoichiometric aspects of major regulatory hubs, such as those involved in chromatin responses to DNA breakage or replication fork impediments. He/she will work closely with his/her mentors and peers while having sufficient freedom to develop his/her projects.

The Lukas lab is intrinsically very interactive and the new postdoc is expected to become an active part of this collaborative spirit. He/she is also expected to disseminate his/her discoveries on internal seminar series and by active participation on international workshops and conferences.

*Place of employment and work*
The employment is at CPR ( ), a Novo Nordisk Foundation center of excellence established in 2007 and embedded in the Faculty of Health and Medical Sciences, University of Copenhagen, to promote basic and applied research on human proteins of medical relevance.

The Center comprises modern laboratories, supercomputer resources and state-of-the-art technological platforms including advanced protein imaging. CPR is an interdisciplinary international environment with English as the main language.

We are located in central Copenhagen, a city with one of the highest qualities of life in the world and a vibrant and highly interactive research environment. The University of Copenhagen has a strong focus on balancing professional life with a family-friendly working environment ( ).

*Terms of salary and employment*
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at DKK 34,365 / approx. EUR 4,612 plus 17.1 % employer paid pension contribution.

The position is temporary for a period of 2 years and the working hours are 37 hours per week.

The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of 2020.

For further information about the position, please contact Research Coordinator Moreno Papetti by e-mail: .

*Application procedure*
Your application must be submitted in English by clicking ‘Apply now’ below.
Your application should include the following documents:

Motivated letter of application.
Curriculum vitae, incl. education and experience.
Names and contact details for 3 references.
Copy of diplomas/degree certificate(s).
List of publications.

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

*Application deadline: 30 April 2020, 23:59 p.m. CET.*

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at .

The Faculty of Health and Medical Sciences comprises approximately 7800 students, 1550 PhD students and 4400 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community.
The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.

Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

Moreno Papetti

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