PhD Scholarship: Signalling in Inflammation and Cell Stress

Updated: about 1 month ago
Job Type: FullTime
Deadline: 24 Nov 2021

A 3-year PhD Scholarship starting 1 February 2022 (or as soon as possible thereafter) is available in the Ubiquitin Signalling and Inflammation Laboratory led by Associate Professor Rune Busk Damgaard.

Our mission
The mission in the Ubiquitin Signalling and Inflammation Laboratory is to unravel fundamental biological concepts and identify druggable signalling mechanisms in inflammatory signalling and cell stress pathways to advance therapy for patients suffering from diseases caused by chronic inflammation and dysregulation of signalling homeostasis, including autoinflammatory conditions and cancer.

The specific interest of the Ubiquitin Signalling and Inflammation Laboratory is to understand how posttranslational modification of proteins by ubiquitin (ubiquitination) regulates cell signalling at the interface of immune signalling, cell stress responses, cell death, and metabolism, and how dysregulation of these signalling mechanisms promotes the development of disease. The lab uses a mix of molecular cell biology, biochemistry, and -omics technologies to investigate and understand how ubiquitin modifications – particularly the enigmatic 'atypical' ubiquitin chains (K6-, K11-, K27-, K29-, K33- and M1-linked chains) – control cellular signalling and functions.

Ubiquitin modifications control a wide variety of signalling pathways, particularly related to cell stress, inflammation, and immunology. When dysregulated, ubiquitin signalling contributes to development of chronic immune disorders and cancer, however the mechanisms behind this remain unclear. This PhD project is part of the lab's major long-term strategy to identify ubiquitin-dependent signalling mechanisms that can be targeted pharmacologically to treat diseases related to chronic inflammatory or cell stress conditions.

Responsibilities and qualifications
The successful candidate holds an M.Sc. degree (or equivalent) in molecular biology, biochemistry, biomedicine, biology, immunology, or a related subject and is curious, ambitious and highly motivated. The candidate is expected to have a strong interest in fundamental scientific discoveries and their translational potential.

In addition, we expect the candidate to have:

  • Hands-on experience with molecular biology and/or biochemical techniques
  • Hands-on experience with mammalian cell culture
  • Strong background knowledge of human or eukaryotic cell biology
  • The ambition, drive, and motivation to succeed within a competitive research field
  • Organisational skills and the ability to work in a team as well as independently
  • Excellent communication skills in written and spoken English

The PhD student will spearhead an ambitious project aiming to identify new mechanisms in ubiquitin signalling that control cell viability during inflammatory and cell stress signalling. Such mechanisms may be druggable and could ameliorate certain aspects of autoinflammatory diseases. The project will involve experimental laboratory work using molecular cell biology, mammalian cell culture systems, and biochemical approaches to understand how ubiquitin modifications control the assembly and stability of key signalling complexes that control cell fate decisions at the interface of pro-inflammatory signalling and cell death. The project will also include cutting-edge mass spectrometry-based proteomics analyses performed in collaboration with the state-of-the-art DTU Proteomics Core.

Experience with any of the following is desirable but not essential:

  • Hands-on experience with immunoblotting (Western blot)
  • Hands-on experience with immunoprecipitation and analysis of multi-protein complexes
  • Hands-on experience with mass spectrometry-based proteomics and proteomics data analysis
  • Research experience in the ubiquitin-proteasome system or related pathways
  • Hands-on experience with CRISPR/Cas9-mediated gene editing

What we offer
The successful candidate will join an ambitious and international research team at the Department of Biotechnology and Biomedicine, Technical University of Denmark (DTU). The Ubiquitin Signalling and Inflammation Laboratory offers a highly ambitious, challenging, encouraging, and dynamic work environment focusing on excellence in research, teaching, and innovation. We work together in a young and fun team and grow together as scientists to tackle important, fundamental research questions. Read more about the lab and our research here: http://bioengineering.dtu.dk/usi

The Ubiquitin Signalling and Inflammation Group is part of the Department of Biotechnology and Biomedicine, Technical University of Denmark. The department is highly interdisciplinary and a leading department within life sciences in Denmark, covering both fundamental, technological, and applied aspects of biomedical research. The successful candidate will join a recently started lab with excellent funding and support. The candidate will benefit from a thriving international and collaborative community and state-of-the-art facilities with access to cutting-edge technologies and equipment.

DTU is a leading technical university globally recognised for the excellence of its research, education, innovation, and scientific advice. We offer a rewarding and challenging job in an international environment.

Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide .

Assessment
The assessment of the applicants will be made by Associate Professor Rune Busk Damgaard together with relevant project partners.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

This is a full-time position for a fixed term of 3 years. The start date is 1 February 2022 (or as negotiated).

The laboratory is located at Søltofts Plads, DTU Lyngby Campus (Greater Copenhagen, Denmark).

Further information
Informal enquiries and requests for further information should be directed to Associate Professor Rune Busk Damgaard (rudam@dtu.dk )

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark .

Application procedure
Please submit your online application no later than 24 October 2021 (Danish time).

Applications must be submitted as a single PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • Motivated application (cover letter)
  • CV
  • List of publications (if any)
  • Master’s (M.Sc.) and Bachelor’s (B.Sc.) degree diplomas, including grade transcripts
  • If your M.Sc. degree is not from Denmark: an Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here )
  • Names and contact details for two academic references

Candidates may apply prior to obtaining their M.Sc. degree but cannot begin before having received it.

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion, or ethnic background are encouraged to apply.


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