PhD scholarship in Protease Degradomics

Updated: about 2 months ago

Apply no later than 26 July 2017
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A 3-year PhD position is available in the section for Protein Science & Signaling Biology at the Department of Biotechnology and Biomedicine (DTU Bioengineering).

The successful applicant will work within the newly established research group ‘Protease Degradomics’ headed by Professor Ulrich auf dem Keller and funded by a Novo Nordisk Foundation (NNF) Young Investigator Award.

In our research group, we apply and develop advanced positional proteomics workflows to identify proteases, elucidate their interactions and determine their substrates in inflammation, repair and regeneration. With a major focus on the skin, we aim at elucidating interdependent proteolytic pathways and their disturbance in disease to provide a basis for the development of novel strategies for diagnostics and therapeutic intervention.

Responsibilities and tasks
The PhD student will work with a team of postdocs and PhD students and in close collaboration with the DTU Proteomics Core Facility to elucidate interconnected activation networks of matrix metalloproteinases (MMPs) in normal and wounded skin. The PhD candidate will establish highly specific and sensitive parallel reaction monitoring (PRM) assays for a panel of MMPs and analyze their interdependent activation in skin cell culture models and genetically modified animals. The ideal candidate for this challenging project has skills in targeted proteomics, tissue culture techniques, sample preparation, animal experimentation and proteomics data interpretation. Moreover, the PhD student is expected to contribute to operation and daily maintenance of Thermo Orbitrap instruments available in the DTU Proteomics Core Facility.

Candidates should have a master's degree in engineering or a similar degree with an academic level equivalent to the master's degree in engineering.

Approval and Enrolment

The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programmes of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide .  

The assessment of the applicants will be made by Professor Ulrich auf dem Keller.

We offer
We offer an interesting and challenging job in an international environment focusing on education, research, scientific advice and innovation, which contribute to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in northern Europe and benchmarks with the best universities in the world.   

Salary and appointment terms
The salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years.

Further information
Further information may be obtained from Professor Ulrich auf dem Keller at . 

You can read more about Department of Biotechnology and Biomedicine at .   

Please submit your online application no later than 26 July 2017. Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one pdf file. The file must include: 

  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and excel spreadsheet here )

Candidates may apply prior to ob­tai­ning their master's degree, but cannot begin before having received it.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.  

The Department of Biotechnology and Biomedicine (DTU Bioengineering) conducts research, educates future bio-engineers, provides scientific advice and innovate within the areas of microbiology, biochemistry, biotechnology and biomedicine. The research at DTU Bioengineering is at the highest international level and focuses on the societal and scientific challenges within the field. Research is conducted within three main areas: Microbial ecology and physiology, Industrial biotechnology and cell factories, and Biomedicine and health. The department has extensive collaboration with national and international research units and industries. DTU Bioengineering has approx. 150 employees, of which 2/3 is scientific staff. The department is located at DTU Lyngby Campus.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 5,800 advance science and technology to create innovative solutions that meet the demands of society; and our 10,600 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government, and public agencies.

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