PhD position in Bispecific Antibody Biomanufacturing

Updated: about 1 month ago

A 3-year PhD position is available within the research group ‘Biotherapeutic Glycoengineering and Immunology’ headed by Professor Steffen Goletz funded by a NNF grant. Our young and rapidly growing research group belongs to the Section of Protein Science and Biotherapeutics at the Department of Biotechnology and Biomedicine. The position will be available from August 2021 or soon thereafter.

In our research group, we apply and develop advanced next generation antibody engineering and glycoengineering technologies to elucidate the role of glycosylations for and within complex immunological networks, microbiome and disease and use these for identifying novel drug targets and generating novel drug candidates and therapeutic strategies. Our main therapeutic interest is within bacterial and viral gastrointestinal and lung diseases as well as a strong focus on immunooncology. Our focus lies within next generation antibody engineering with multimodal antibody constructs, phage display technologies, molecular and cellular glycoengineering, and mammalian bioprocess engineering as well as glycoimmunology, microbiome glycoengineering, glycomic and glycomimetic display systems. We also have a strong focus on innovation and entrepreneurship.

Responsibilities and qualifications
The PhD student will work with a team of Senior scientists, postdocs and PhD students and in close collaboration with national and international collaborators to establish a platform of next generation glycoengineered biotherapeutics with the focus on creating a novel biomanufacturing platform for faster and highly reproducible biomanufacturing of bispecific antibody therapeutics.

The ideal candidate for this challenging project is highly motivated and has skills in bioprocessing and bioreactor handling for mammalian cell production as well as practical experience in gene editing, protein purification and analysis, as well as molecular biology.  Knowledge and skills in antibody engineering and proteomics would be of advantage. Moreover, the PhD student is expected to contribute to inter connective team tasks.

Candidates should have a master's degree in biotechnology, biochemistry, protein chemistry, , molecular biology, biology, cell biology or alike.

Approval and Enrolment
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programs of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide .  

The assessment of the applicants will be made by Professor Steffen Goletz.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms
The salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years.

The position will be located at the DTU Lyngby campus in the recently established research building 225 hosting state-of-the-art laboratories for e.g. protein science, phage display, microbiome research, immunology and cellular research, mammalian bioprocessing as well as the DTU Proteomics Core.

Further Information
Additional information may be obtained from Prof. Dr. Steffen Goletz,

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark .

Please submit your online application no later than 23 June 2021 (Danish time).

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here )

You may apply prior to ob­tai­ning your master's degree but cannot begin before having received it.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,900 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

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