PhD in development of multi-specific protein therapeutics

Applicants are invited for a PhD fellowship/scholarship at Graduate School of Technical Sciences, Aarhus University, Denmark, within the Biological and Chemical Engineering programme. The position is available from 01 May 2023 or later.

Title:
PhD in development of multi-specific protein therapeutics

Research area and project description:
A large number of diseases is caused by pathogenic molecules upon encounter of the human body via the airways, skin or intestine. Severe reactions including anaphylaxis represent life threatening conditions in patients, which are specifically susceptible, e.g. due to allergic sensitization. This ambitious and interdisciplinary project will establish novel and unorthodox treatment strategies based on bi- and multi-specific molecular engagers that enable efficient trapping of culprit antigens and thereby interfering with severity and course of disease.

The candidate will be part of the Immunological Biotechnology group in the Section of Medical Biotechnology and focus on the development of novel ligands and establish, produce, characterise, evolve and analyse multi-specific, multi-modal molecules based on immunoglobulin scaffolds. Functional and structural characterisation will be performed as foundation for further development.

For more information on the group: https://bce.au.dk/en/research/key-areas-in-research-and-development/medical-biotechnology/immunological-biotechnology

We are looking for an open minded, curious person with strong interest in medical biotechnology and drug development. The student will join a team of researchers, experienced technicians and students at different levels of their education in an international environment where commitment, helpfulness, flexibility, and close collaboration are core values.

The study is part of a collaborative research project funded by the Aarhus University Research Foundation and a collaboration with research institutions in Denmark and Germany. Hence, part of the project might be performed abroad.

Project description. For technical reasons, you must upload a project description. Please simply copy the project description above, and upload it as a PDF in the application.

Qualifications and specific competences:
Applicants must have a relevant Master´s degree or at least one year of a Master´s degree in Biotechnology, Molecular Medicine, Molecular Biology or the like. Experience with protein biotechnology, combinatorial technologies, flow cytometry and immunological techniques are considered as advantage. Oral and written communication skills in English are required. The applicant must be able to present results at international conferences and publish in international peer-reviewed journals. The applicant should be enthusiastic about working in an international and interdisciplinary academic environment.

Place of employment and place of work:
The place of employment is Aarhus University, and the place of work is Gustav Wieds Vej 10, 8000 Aarhus C, Denmark.

Contacts:
Applicants seeking further information are invited to contact Associate Professor Edzard Spillner, e.spillner@bce.au.dk

How to apply:
Please follow this link to submit your application.

Application deadline is 28 February 2023 at 23:59 CET. Preferred starting date is 1 May 2023.

For information about application requirements and mandatory attachments, please see our application guide .

Please note:

• The programme committee may request further information or invite the applicant to attend an interview.
• Shortlisting will be used, which means that the evaluation committee only will evaluate the most relevant applications.