PhD Fellowship to Study Human DNA Replication Programme and Genome Integrity

Updated: about 2 months ago
Job Type: FullTime
Deadline: 15 Jan 2022

We are looking for a highly motivated PhD student with a strong background in molecular and cell biology to join the young recently established lab of Kumar Somyajit studying DNA replication and genome stability at the interface of metabolic signalling at the Functional Genomics & Metabolism Research Unit at Department of Biochemistry and Molecular Biology, SDU.

Research Project and Role
DNA replication is essential for a cell to multiply and transfer genetic information to its daughters. However, a plethora of extrinsic and intrinsic factors challenge individual DNA replication forks and cause replication stress, a hallmark of all cancer types and a range of developmental disorders. Yet, we know very little about the mechanisms that align DNA replication activities to potentially harmful endogenous threats such as metabolic stress, and thereby limiting the detrimental consequences of abnormal DNA replication.

As a PhD studen t in the Somyajit group you will be engaged in a highly interdisciplinary project uncovering regulatory foundations of human DNA replication and genome protection by focusing on how active reorganization of the replisome motor is achieved in response to natural fluctuations in metabolic pathways, inevitable during early development and cancer. You will combine advanced quantitative cell biology approaches such as quantitative-image-based-cytometry- QIBC, time-lapse microscopy, super-resolution microscopy, DNA fiber techniques, with classical genetics and biochemistry to reveal novel regulations of replisome velocity and identify how cancer-specific metabolic changes impact DNA replication speed, replisome integrity and cell cycle in human cells.

You will interact and collaborate closely with other researchers in the Somyajit and the Mandrup groups as well as with members of the other research groups within FGM and at the Department of Biochemistry and Molecular Biology.

Qualifications/Requirements
We are looking for highly motivated, dedicated, and ambitious candidates with:

  • A Master's degree in Life Science, preferably Molecular Biology, Cell Biology, Biomedicine
  • A curious mind-set with a strong interest in fundamental Cell cycle, DNA replication and Genome integrity
  • Relevant laboratory experience in molecular cell biology and biochemistry
  • Strong communication and collaborative skills and an interest in working in an interdisciplinary environment
  • Proficiency in spoken and written English.

Know-how in Genome integrity field, stem cell culture, light microscopy, bioinformatics will be considered an advantage.

Deadline: 15 January 2022.

Please see the full call, including how to apply, on http://www.sdu.dk .

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