Department of Pharmacy
Faculty of Health and Medical Sciences (SUND)
University of Copenhagen
The Department of Pharmacy is offering a three-year PhD fellowship to investigate the use of phospholipase-responsive lipid-based drug delivery systems for improved anti-inflammatory therapeutics, in particular against psoriasis. The PhD project will be carried out within the recently established LEO Foundation Center for Cutaneous Drug Delivery (LFCCDD), which integrates several disciplines, including molecular biology, immunology, microbiology, physical chemistry, peptidomics and pharmaceutics, to perform state-of-the-art research and to create innovative solutions within cutaneous drug delivery of both small and large molecules.
The successful applicant will be a member of the Novel Drug Delivery Systems group and will have the opportunity for cross-disciplinary research in collaboration with the other sections of the Center as well as external collaborators.
The fellowship is available from the 1st of November 2021 or as soon as possible thereafter.
Psoriasis is a chronic skin disease, affecting around 2 % of the population. Apart from the requirement of frequent dosing of topical formulations, which leads to high non-compliance in treatment, the occurrence of flare-ups makes it difficult for the patients to control the disease. Especially the presence of recurrent psoriasis plaques on exposed parts of the body, such as the face, hands or feet, has considerably negative impact on the quality of life. In this project, lipid-based self-assembly systems, such as cubosomes and hexosomes loaded with anti-inflammatory drugs, displaying drug release in response to the presence of phospholipase A2 will be developed and optimized. The primary function of PLA2 enzymes is to hydrolyze glycerophospholipids, causing the release of pro-inflammatory unsaturated free fatty acids and lysophospholipids, making it an important regulator in the early phase of chronic inflammatory diseases. Therefore, this project aims to develop inflammation-responsive drug delivery systems, allowing improved control of the disease by releasing drug substance only in response to inflammatory flare-ups. More in detail, focus will be placed on modifying the phospholipid concentration, acyl chain length and unsaturation, head group composition, and presence of cholesterol, as well as drug loading to develop the most efficient drug delivery system. The drug delivery systems will be characterized using a range of analytical techniques and their skin permeation will be investigated.
Principal supervisor: Associate Professor Andrea Heinz
Co-supervisor: Professor Martin Malmsten
Your key tasks as a PhD fellow at the Faculty are to:
- Carry through an independent research project under supervision
- Write scientific manuscripts and the PhD thesis on the grounds of your research project
- Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
- Obtain experience with teaching and other types of dissemination related to your PhD project
- Participate in all Center activities
- Participate in the undergraduate teaching of students in pharmaceutical sciences
- Participate in national and international conferences and scientific meetings
- Stay at an external research institution, preferably abroad
We are looking for a highly motivated and enthusiastic individual with the following competencies and experience:
As an applicant you must have:
- Obtained a relevant Master´s degree prior to the starting date
- Fluency in English and excellent communication skills, both oral and written.
- The ability to work in an interdisciplinary environment.
- The ability to travel for performing experiments at collaborators.
The ideal candidate for this project has extensive hands-on experience with colloidal drug delivery systems, including their formulation and characterization using a variety of analytical techniques. Experience with skin permeation experiments is an advantage.
Key criteria for the assessment of applicants
- Professional qualifications relevant to the PhD programme
- Relevant work experience
- Previous publications
- The grade point average achieved
- Other professional activities and achievements
- Language skills
Terms of employment
The employment as PhD fellow is full time and for 3 years.
It is conditioned upon the applicant’s successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project to the Graduate School of Health and Medical Sciences.
The PhD study must be completed in accordance with The Ministerial Order on the PhD program (2013) and the Faculty’s rules on achieving the degree.
The PhD student is expected to be affiliated to the graduate program in pharmaceutical sciences, Drug Research Academy .
Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around DKK 27,594 (approx. 3,679 EUR) (taxable) plus pension (April 2020 level).
Your online application, in English, must be submitted electronically through the University of Copenhagen job portal.
Your application must include following documents/attachments – all in PDF format:
- Cover letter (approx. 1 page) describing your background, qualifications, interest and motivation for applying for this position
- Full CV
- Diploma and transcripts of records: Master’s degree diploma (including grade transcripts for bachelor´s and master´s degrees). Applicants with a Master´s degree from abroad should also enclose a short description of the grading scale used.
- Other information for consideration, e.g. list of publications and relevant certificates
- Names and contact details of references and/or recommendation letters
Deadline for application
15th of September 2021, 23:59 GMT+1. Please note that only online applications will be accepted.
Applications received later than this date, or which do not live up to the abovementioned requirements, will not be considered.
Post application procedure
After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.
The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.
Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.
The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.
Interviews are expected to be held in September.
You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/
For further information, applicants may contact supervisor Andrea Heinz (email@example.com ) or PhD administrator Marianne W. Jørgensen (firstname.lastname@example.org , phone: +45 35 33 64 49).
For more information on working and living in Denmark visit http://ism.ku.dk (International staff mobility) and https://www.workindenmark.dk
University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.
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