PhD fellowship in molecular immunology at the LEO Foundation Skin Immunology Research Center (SIC)

Updated: 13 days ago
Deadline: 30 May 2021

Faculty of Health and Medical Sciences
University of Copenhagen

We are offering a PhD fellowship in ubiquitin signalling and immunology to commence 1 October 2021 or as soon as possible hereafter.

Our group and research
We aim to uncover novel molecular mechanisms that regulate inflammation and innate immune responses. Through this, we aim to advance our understanding of the molecular aetiology of inflammatory skin diseases and other immune disorders.

A central focus of our research is to elucidate the role and regulation of the ubiquitin system, which plays a central role in regulating inflammation and immune responses in the skin, gastrointestinal tract and other organs/tissues. The ubiquitin system is an emerging drug target and through detailed studies of the molecular mechanisms underpinning ubiquitin-based immune signalling, we aim to identify “druggable” molecular processes that ultimately may have clinical benefit in the treatment of skin diseases and other immune-driven pathologies.

We believe in teamwork and have an inclusive and supportive working environment in an international, open-minded atmosphere with a diversity of nationalities among group members and at the Department at large.

As part of SIC, our group is located on the 12th floor in the award-winning Maersk Tower, which offers ultra-modern facilities and a vibrant international research environment with focus on the development of early-career scientists. Based on a grant from the LEO Foundation of more than 50 million EUR, SIC aims to unite leading Danish and international researchers in immunology and skin disease to provide new knowledge to enable better diagnostics and more effective treatments for a wide range of inflammatory skin diseases. Our mission is that SIC will become a world-leading center for research and education in skin and skin diseases. Further information on the center can be found at: https://sic.ku.dk .

Project description
The project will focus on the role of the ubiquitin machinery in immune regulation and inflammation, with a particular focus on these processes in the skin. The successful candidate will employ biochemistry, molecular biology, and cell culture systems generated by the host lab to explore molecular mechanisms underpinning ubiquitin-dependent immune signalling and will work with other team members to investigate their impact on immune regulation.

The project requires the use of a wide range of experimental methodologies, including cell culture systems, biochemical, molecular and cell biology techniques, including but not limited to mass spectrometry analysis of protein complexes and ubiquitin conjugates, protein purification by FPLC, genome editing (CRISPR-cas9), fluorescence imaging, biochemical analysis of signalling pathways.

Principal supervisor isProf. Mads Gyrd-Hansen, LEO Foundation Skin Immunology Research Center (SIC), Department of Immunology and Microbiology, E-mail: mgyrd@sund.ku.dk , Direct Phone: +45 2434 0323.

Start:                  1 October 2021

Duration:          3 years as a PhD student

Job description
Your key tasks as a PhD student at SUND are to:

  • Carry through an independent research project under supervision 
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Participate in active research environments including a stay at another research team
  • Obtain experience with teaching or other types of dissemination related to your PhD project
  • Teach and disseminate your knowledge
  • Write a PhD thesis on the grounds of your project

Key criteria for the assessment of applicants
Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project e.g. the applicant holds a master in biochemistry or equivalent. Prior experimental experience with mass spectrometry, the ubiquitin system, analysis of signal transduction pathways, and/or relevant cellular in vitro model systems is preferred. It is a condition that your Master’s degree is considered to be equivalent to a Danish Master’s degree.

Other important criteria are:

  • The grade point average achieved
  • Professional qualifications relevant to the PhD project
  • Previous publications
  • Relevant work experience
  • Curious mind-set with a strong interest to explore novel mechanisms of immune regulation
  • Language skills

Place of employment
The place of employment is the LEO Foundation Skin Immunology Research Center (SIC), Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories on the 12th floor of the Mærsk Tower and access to state-of-the-art core facilities for flow cytometry, single cell sequencing, microscopy, animal facilities etc.

Terms of employment
The employment as PhD fellow is full time and for 3 years and is to commence 1 October 2021 or as soon as possible hereafter.

The employment is conditioned upon the applicant’s success­ful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agree­ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins at around 27,780 DKK /approx. 3,730 EUR (April 2021-level) plus pension.

Questions
For specific information about the PhD fellowship, please contact the principal supervisor.

General information about PhD studies at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/

Application procedure
Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format: 

  • Motivated letter of application (max. one page)
  • CV incl. education, experience, language skills and other skills relevant for the position
  • Master of Science diploma and transcript of records. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor should be included
  • Publication list (if any)
  • Application deadline:  30 May 2021, 23.59pm CET

    We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the above-mentioned requirements.

    The further process
    After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

    The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

    Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

    You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/ .

    The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

    Interviews are expected to be held in June/July 2021.

    The Faculty of Health and Medical Sciences comprises approximately 7850 students, 1700 PhD students and 4800 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community. The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position. 


    Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.


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