PhD fellowship in genome stability maintenance

Updated: about 2 months ago
Deadline: 30 Nov 2019

Novo Nordisk Foundation Center for Protein Research, University of Copenhagen

A three-year PhD position commencing as soon as possible is available in the Mailand Group at Novo Nordisk Foundation Center for Protein Research (CPR – www.cpr.ku.dk ), University of Copenhagen, Denmark.

Mailand Group at CPR

CPR promotes basic and applied discovery research on human proteins with medical relevance. The Center is a strong hub for research on genome stability maintenance and human disease, comprising modern laboratories and state-of-the-art facilities within protein science. Research in the Mailand Group aims to understand how signaling via post-translational protein modifications orchestrate and regulate cellular responses to DNA damage and replication stress. We combine systems-wide proteomics- and genomics-based approaches with methods within cell biology, biochemistry and advanced imaging to identify and functionally characterize cellular signaling responses that prevent genome instability and disease onset. We offer a vibrant, ambitious and highly international research environment, as well as access to cutting-edge facilities within protein science, including state-of-the-art proteomics and microscopy platforms.

For more information please visit: http://www.cpr.ku.dk/research/proteinsignaling/mailand/

Job description and projects

The successful candidate will join a multidisciplinary EU-funded Marie Sklodowska Curie International PhD training network aiming to understand the roles of DNA damage signalling and repair processes in development and disease. Using proteomics-based screening approaches, we are able to comprehensively map the cellular proteins recruited to sites of DNA damage, providing detailed and unprecedented insights into the dynamics and identities of the cellular proteins operating in the context of DNA lesions to safeguard genome stability. The PhD project aims to mechanistically dissect the functions of prospective novel and uncharacterized human genome stability maintenance factors that we recently identified in such screens. For these studies, the successful candidate will have the opportunity to apply a broad range of advanced cell-, biochemistry- and microscopy-based methodologies, as well as cutting-edge proteomics- and CRISPR-Cas9-based screening approaches.

Projected start date: January 2020.

Eligibility criteria

The candidate must fit the following eligibility criteria in order to obtain the position:

  • You must not have resided or carried out your main activity (work, studies, etc.) in Denmark for more than 12 months in the 3 years immediately prior to your recruitment - unless as part of a procedure for obtaining refugee status under the Geneva Convention (1).
  • You must be an Early Stage Researcher (ESR): at time of recruitment you must be in the first 4 years (full-time equivalent research experience (2) of your research career and must not have been awarded a doctoral degree.

Qualifications

We are looking for a highly motivated and ambitious candidate with qualifications corresponding to a Master’s degree in the life sciences. Other important selection criteria are:

  • Professional qualifications relevant to the PhD project
  • Relevant work experience, preferably in the genome stability research field
  • Experience with mammalian cell culture and biochemistry
  • An open-minded, flexible and enthusiastic personality capable of interacting well within a group
  • Excellent communication skills and fluency in English
  • A track record of international mobility

Terms of employment

The employment as PhD fellow is full time and for 3 years and is conditioned upon the applicant’s success­ful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agree­ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State, and according to the rules and regulations laid down by the European Union’s Horizon 2020 Marie Skłodowska-Curie Action European Training Network. Depending on seniority, the monthly salary begins around 27,362 DKK /approx. 3.663 EUR (October 2019-level) plus pension.

Questions

For specific information about the PhD fellowship, please contact the principal supervisor, Prof. Niels Mailand (email: niels.mailand@cpr.ku.dk ).

General information about PhD study at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/

Application procedure

Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format:

  • Motivated letter of application (max. one page)
  • CV incl. education, experience, language skills and other skills relevant for the position
  • Master of Science diploma and transcript of records. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will suffice
  • Publication list (if possible)
  • For those applicants whose principal language of instruction during their BSc/MSc was not English it will a be an advantage if they enclose IELTS or TOEFL test scores or equivalent proof of English skills, however it will be at the discretion of the supervisors during the interviews to evaluate the English skills.

    Application deadline: 30 October 2019, 23.59pm CET

    We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

    The further process

    After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

    You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

    The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

    [1] 1951 Refugee Convention and the 1967 Protocol

    [2] This is measured from the date when a researcher obtained the degree which would formally entitle him or her to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher is recruited, irrespective of whether or not a doctorate is or was ever envisaged.

    The Faculty of Health and Medical Sciences comprises approximately 7500 students, 1500 PhD students and 3200 employees. The Faculty advances the field of health sciences through its core activities: research, teaching, knowledge sharing and communication. With basic research fields ranging from molecular studies to studies of society, the Faculty contributes to a healthy future through its graduates, research findings and inventions benefitting patients and the community. The University of Copenhagen wishes to reflect the surrounding community and invites all regardless of personal background to apply for the position.


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