PhD fellow positions in Protein Interaction Studies

Updated: about 1 month ago
Deadline: 26 May 2021

One or more PhD scholarships are available from August 15th, 2021, or as soon as possible thereafter, in the group of Assistant Professor Amelie Stein, Section of Computational and RNA Biology, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. The research in the Stein group aims to link protein biophysics and genomics using computational and experimental methods.

Details of the PhD projects
The PhD students will work on disentangling the consequences of missense variants in proteins on their stability, interactions, and function. Both students with focus on experimental work as well as those interested in computational modelling of protein structure and interactions are encouraged to apply. Long-term goals in our research group and the PRISM Centre we are part of include developing predictive and mechanistic models for how genomic variation in protein-coding regions (protein variants) affect the stability, interactions and function of proteins. For an introduction to the research see e.g. our recent review (Stein et al, TiBS, 2019, https://doi.org/10.1016/j.tibs.2019.01.003 . Research topics for the PhD projects include:

  • Testing interaction properties of clinically relevant and designed protein variants
  • Structure-based modelling of protein interactions and the consequences of perturbations

The Ph.D. student(s) will work together with scientists from several disciplines in a highly international environment, thus a good level of spoken and written English is required.

Principal supervisor is Associate Professor Jeppe Vinther, Department of Biology, University of Copenhagen, email: jvinter@bio.ku.dk , phone +45 22840780.

Job description
The position is available for a 3-year period and your key tasks as a PhD student at SCIENCE are:

  • To manage and carry through your research project
  • Attend PhD courses
  • Write scientific articles and your PhD thesis
  • Teach and disseminate your research
  • To stay at an external research institution for a few months, preferably abroad
  • Work for the department

Formal requirements
We are seeking motivated and strong applicants with a MSc degree in molecular biology, biochemistry, biophysics, bioinformatics, physics, chemistry or similar fields with prior research experience (e.g. MSc projects) within one or more of these areas:

  • Molecular biology techniques (cloning, transfection, Wester Blots)
  • Yeast genetics
  • Structural bioinformatics, especially with focus on protein interactions or complexes
  • Computational analyses of the effects of protein sequence variation on protein stability, interactions and function

It will also be advantageous to have experience with one or more of the following:

  • Yeast-two-hybrid or other high-throughput approaches for protein interaction detection
  • The Rosetta software for protein structure modelling
  • Machine learning applications to protein modelling

Terms of employment
The position is covered by the Memorandum on Job Structure for Academic Staff.

Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

The starting salary is currently at a minimum DKK 333.464 (approx. €44,461) including annual supplement (+ pension up to DKK 54,191). Negotiation for salary supplement is possible.

Application Procedure
The application, in English, must be submitted electronically by clicking APPLY NOW below.

Please include

  • A cover letter (max 1. page) explaining your background, key skills and how they are relevant to our research, and your motivation for applying
  • Curriculum vitae (max 2. pages) including educational background and previous research experience
  • List of publications (including preprints and papers in active preparation)
  • Diploma and transcripts of records (BSc and MSc). If you do not yet hold your MSc and would like to apply, please submit a letter from your supervisor regarding your expected graduation date
  • Contact details for 1-2 former supervisors (no reference letters should be attached)

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

The deadline for applications is 26 May 2021 23:59 GMT +2.

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee. Afterwards an assessment committee will be appointed to evaluate the selected applications. The applicants will be notified of the composition of the committee and the final selection of a successful candidate will be made by the Head of Department, based on the recommendations of the assessment committee and the interview committee.

The main criterion for selection will be the research potential of the applicant and the above mentioned skills. The successful candidate will then be requested to formally apply for enrolment as a PhD student at the PhD school of Science. You can read more about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/ .

Questions
For specific information about the PhD scholarship, please contact Assistant Professor Amelie Stein (amelie.stein@bio.ku.dk )

General information about PhD programmes at SCIENCE is available at https://www.science.ku.dk/phd .


Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.


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