MSCA-DN GlyCanDrug: DC5. PhD scholarship in Combotope-specific single chain fragments (scFv) antibodies by Phage Display Technologies.

Updated: 3 months ago
Job Type: FullTime
Deadline: 01 Jan 2024

27 Nov 2023
Job Information
Organisation/Company

Technical University Of Denmark
Department

Department of Chemistry
Research Field

Chemistry » Organic chemistry
Researcher Profile

First Stage Researcher (R1)
Country

Denmark
Application Deadline

1 Jan 2024 - 23:59 (Europe/Copenhagen)
Type of Contract

Temporary
Job Status

Full-time
Hours Per Week

37
Offer Starting Date

1 Feb 2024
Is the job funded through the EU Research Framework Programme?

HE / MSCA
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Offer Decscription

A PhD studentship in Combotope-specific single chain fragments (scFv) antibodies by Phage Display Technologies, funded by the HORIZON Europe Marie Skłodowska-Curie Doctoral Networks (MSCA-DN) project GlyCanDrug, is available at Department of Biotechnology and Biomedicine at Technical University of Denmark (DTU). The project will be under the supervision of Professor Andreas Hougaard-Laustsen-Kiel and, Dr. Ola Blixt (co-supervisor, Combotope Therapeutics).

Project Description and responsibilities:

DC5 is responsible for several tasks related to the development of cutting-edge anti-combotope scFv antibodies as part of the GlyCanDrug program. The main objectives of DC5 includes preparation of synthetic combotope peptides, Implement and further develop the iDEAL phage display antibody discovery platform, molecular-level study of combotope/scFv interactions, specificity assessment and targeting validation using various engineered cancer cell models and human patient tissue samples including scFv-functionalized liposomes and scFv-engineered NK cells. This training will involve understanding the implications of scFv antibodies as potential chimeric antigen receptors (CAR) to enhance NK cells' ability to kill cancer cells. The work conducted by DC5 will contribute to the ambitious studies of the GlyCanDrug program and lay the groundwork for future implementation beyond the project's duration.

Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see DTU's rules for the PhD education .

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Further information
Further questions about the project should be directed to Andreas H. Laustsen-Kiel [email protected] or Ola Blixt [email protected] or [email protected] .  

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark . Furthermore, you have the option of joining our monthly free seminar “PhD relocation to Denmark and startup “Zoom” seminar ” for all questions regarding the practical matters of moving to Denmark and working as a PhD at DTU.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science- and biotech industries and point towards innovation, new businesses, and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 400 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

 


Requirements
Research Field
Chemistry » Organic chemistry
Education Level
Master Degree or equivalent

Languages
ENGLISH
Level
Excellent

Research Field
Chemistry » Organic chemistry

Internal Application form(s) needed
GlyCanDrug_DC5 position.PDF
English
(158.92 KB - PDF)
Download
GlyCanDrug_General call for applicationsApplication form_Euraxess.PDF
English
(381.04 KB - PDF)
Download
Additional Information
Work Location(s)
Number of offers available
1
Company/Institute
Technical University of Denmark, Department of Chemistry
Country
Denmark
State/Province
Copenhagen
City
Copenhagen
Postal Code
2800
Street
Kemitorvet 207

Where to apply
E-mail

[email protected]

Contact
City

Kgs. Lyngby, Copenhagen
Website

https://www.kemi.dtu.dk/
Street

Kemitorvet 207
Postal Code

2800
E-Mail

[email protected]

STATUS: EXPIRED

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